CMTM1 Activators
Forskolin, by increasing intracellular cAMP, activates protein kinase A (PKA), a kinase that can phosphorylate proteins within the CMTM1 signaling network. Similarly, IBMX maintains elevated levels of cAMP, ensuring sustained PKA activation. PMA is a robust activator of protein kinase C (PKC), which could have downstream effects on CMTM1 activity through phosphorylation of associated proteins. Lithium chloride offers a different modulatory effect by inhibiting glycogen synthase kinase-3 (GSK-3), potentially leading to enhanced CMTM1 expression or function through altered protein interactions. SB203580, while primarily a p38 MAPK inhibitor, may induce compensatory activation in other pathways, which might influence CMTM1's activity. PD98059, by inhibiting MEK, could similarly lead to shifts in regulatory pathways affecting CMTM1. LY294002's inhibition of PI3K/Akt pathway also contributes to these complex signaling cascades, with possible implications for CMTM1 regulation.
Compounds like curcumin and resveratrol activate transcriptional pathways, such as NF-κB and sirtuins, which can have implications for CMTM1 expression or function. EGCG, with its antioxidant properties, potentially affects kinase and transcription factor activities, which could intersect with the regulation of CMTM1. Anisomycin, through JNK signaling, influences stress-related pathways with potential effects on CMTM1. Sulforaphane, an activator of the Nrf2 pathway, represents another route through which cellular oxidative stress responses might modulate CMTM1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which in turn can activate PKA. PKA has been known to phosphorylate a variety of proteins and could enhance CMTM1 signaling if CMTM1 is a substrate for PKA or if PKA phosphorylates a protein that interacts with CMTM1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. Elevated cAMP levels can activate PKA, which may intersect with CMTM1 regulatory pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which can phosphorylate target proteins that may include those in the CMTM1 pathway, modulating its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase involved in numerous signaling pathways. Inhibition of GSK-3 can result in the activation of pathways that may upregulate CMTM1 expression or function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor; however, inhibition can lead to compensatory activation in related pathways that may influence CMTM1 expression or activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which may result in compensatory effects in other pathways that regulate CMTM1 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and by inhibiting PI3K/Akt pathway, it can lead to adjustments in downstream signaling pathways that might intersect with the regulation of CMTM1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates several signaling pathways, including the NF-κB pathway, which in turn can regulate a variety of proteins and genes, potentially including CMTM1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins and modulates the NF-κB pathway, which may influence CMTM1 expression or function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) has antioxidant properties and can modulate signaling pathways through its effects on various kinases and transcription factors that may be involved in CMTM1 regulation. | ||||||