CLRN2 Activators
CLRN2 Activators encompass a group of compounds that facilitate the functional activity of CLRN2 through modulation of calcium signaling pathways. These activators include both direct and indirect mechanisms by which intracellular calcium dynamics and calcium-dependent processes are altered, resulting in the enhanced activation of CLRN2. For example, the calcium ionophore A23187 directly increases intracellular Ca2+ levels, which can lead to the activation of Ca2+-dependent signaling pathways and protein kinases. These kinases may then interact with and activate CLRN2. Similarly, thapsigargin and cyclopiazonic acid disrupt calcium homeostasis in the endoplasmic reticulum, leading to increased cytosolic calcium levels which then activate Ca2+-dependent pathways that can enhance the activity of CLRN2.
Furthermore, other compounds like BAPTA-AM and nimodipine work indirectly by modulating the cell's calcium buffering capacity or by blocking voltage-gated calcium channels, respectively. This modulation can result in compensatory cellular responses that ultimately lead to the activation of CLRN2. Inhibitors like SKF-96365, 2-APB, and Xestospongin C alter calcium entry or release within the cell, leading to the activation of compensatory pathways that enhance the activity of CLRN2. Additionally, compounds such as ML-9 and KN-93, which inhibit specific kinases like MLCK and CaMKII, may lead to the indirect activation of CLRN2 through the disruption of downstream calcium/calmodulin-dependent processes. Lastly, W-7's antagonism of calmodulin disrupts calmodulin-mediated signaling, which can in turn activate pathways leading to the enhancement of CLRN2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular Ca2+ concentrations, which can activate Ca2+-dependent protein kinases that interact with CLRN2, leading to its functional activation. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a calcium chelator that, once inside the cell, can buffer calcium and indirectly enhance the activity of calcium-responsive elements, potentially leading to the activation of CLRN2 as part of a compensatory cellular response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the ER Ca2+ ATPase, leading to increased cytosolic Ca2+ levels and activation of Ca2+-dependent signaling pathways, which could enhance the functional activity of CLRN2. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid inhibits calcium pumps like SERCA, leading to an increase in cytosolic calcium levels, which can activate Ca2+-dependent kinases and phosphatases involved in CLRN2 activation. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates the ryanodine receptor, altering intracellular calcium dynamics, which can lead to the activation of calcium-dependent pathways that enhance the activity of CLRN2. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated Ca2+ entry and store-operated channels; its use can result in altered Ca2+ homeostasis and activation of signaling pathways that potentially enhance CLRN2 activity. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine blocks voltage-gated calcium channels, which can alter intracellular Ca2+ signaling and potentially enhance compensatory pathways that activate CLRN2. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits IP3 receptors and store-operated calcium entry, which can affect intracellular calcium signaling and potentially lead to the activation of pathways involving CLRN2. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9 is a kinase inhibitor that blocks myosin light-chain kinase (MLCK) which can interfere with calcium/calmodulin-dependent processes, indirectly enhancing pathways that activate CLRN2. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII); modifying CaMKII activity can lead to altered cellular responses that enhance the activation of CLRN2. | ||||||