Cldn27 Inhibitors
Cldn27 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the claudin-27 (Cldn27) protein, a member of the claudin family. Claudins are integral membrane proteins that play a critical role in the formation and maintenance of tight junctions, which regulate the paracellular pathway in epithelial and endothelial tissues. Tight junctions serve as barriers that control the movement of ions, water, and solutes between cells. Cldn27 is involved in maintaining the integrity and selectivity of these tight junctions, contributing to the regulation of ion permeability across cell layers. Inhibitors of Cldn27 disrupt its function by interfering with its ability to form or stabilize tight junctions, leading to alterations in the permeability and barrier properties of the epithelial or endothelial cells where Cldn27 is expressed.
Cldn27 inhibitors bind to the extracellular loops or the transmembrane regions of the claudin protein, hindering its interactions with neighboring claudin molecules or other tight junction components. This disruption in claudin-claudin interactions can affect the structural organization of tight junctions and modify the paracellular transport of ions and other small molecules. By inhibiting Cldn27, researchers can investigate the specific role this protein plays in tight junction dynamics and epithelial barrier function. Such studies are useful for understanding how tight junctions contribute to tissue homeostasis, ion selectivity, and the maintenance of concentration gradients across epithelial layers. The inhibition of Cldn27 offers insights into the mechanisms by which tight junction integrity is regulated, enabling the exploration of how claudins contribute to diverse physiological processes across different tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Broad-spectrum kinase inhibitor targeting multiple signaling pathways, including PKC. Its interference with PKC cascades disrupts downstream events, indirectly impeding Tmem235 activity within cellular processes reliant on PKC-mediated signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor disrupting the PI3K-AKT signaling axis. By hindering this pathway, Wortmannin indirectly downregulates Tmem235 expression and function, as the protein is intricately connected to PI3K-associated cellular responses in various tissues. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Specific p38 MAPK inhibitor attenuating Tmem235 indirectly. Tmem235's involvement in p38 MAPK-regulated processes makes it susceptible to disruption when the kinase is inhibited, altering downstream events and impeding the protein's functional outcomes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK inhibitor impacting the MAPK pathway. Tmem235, influenced by MAPK signaling, sees reduced expression and activity in the presence of U0126. The inhibition of MEK cascades indirectly hampers Tmem235 function within MAPK-associated cellular responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibitor of PI3K/AKT pathway, influencing Tmem235 indirectly. By disrupting this pathway, LY294002 leads to downstream alterations in Tmem235-related processes, ultimately impeding the protein's expression and functional outcomes within cellular contexts. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor affecting Tmem235 indirectly. Tmem235, intertwined with JNK-regulated pathways, experiences disruptions in expression and function in the presence of SP600125. The inhibition of JNK cascades indirectly impedes Tmem235 within JNK-associated cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibitor of MEK/ERK pathway, indirectly impacting Tmem235. The disruption of this pathway by PD98059 leads to altered expression and function of Tmem235, as the protein is intricately linked to MEK/ERK-mediated cellular responses in various tissues. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor indirectly influencing Tmem235. Given Tmem235's connection to TGF-β signaling, the inhibition of its receptor by SB431542 disrupts downstream events, indirectly hampering Tmem235 expression and functional outcomes within TGF-β-associated processes. | ||||||
Phytosphingosine | 554-62-1 | sc-201385 sc-201385A | 5 mg 25 mg | $100.00 $419.00 | 4 | |
STAT3 inhibitor impacting Tmem235 indirectly. Tmem235, modulated by STAT3-regulated pathways, experiences disruptions in expression and function in the presence of SP0103. Inhibiting STAT3 cascades indirectly impedes Tmem235 within STAT3-associated cellular processes. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
JAK2 inhibitor indirectly affecting Tmem235. Tmem235, intertwined with JAK2-mediated signaling, undergoes disruptions in expression and function when JAK2 is inhibited by AG490. The inhibition of JAK2 cascades indirectly hampers Tmem235 within JAK2-associated cellular responses. | ||||||