Cldn27 Activators
Tmem235, or transmembrane protein 235, is a protein encoded by the TMEM235 gene. It is primarily localized in the apical plasma membrane and cytoplasm and is expressed in various structures, including the brain, gut, heart, liver, and metanephros. Its functional role, as suggested by its expression pattern and localization, is likely pivotal in cellular processes within these tissues. However, the exact biological function of Tmem235 remains to be fully elucidated. Its presence in critical organs such as the heart and liver suggests a role in essential physiological processes, potentially involving cellular signaling, ion transport, or metabolic regulation. The activation of Tmem235, given its transmembrane nature, is likely intricately linked to cellular signaling pathways. In the absence of direct activators, the focus shifts to indirect mechanisms that can influence its activity. Given its expression in metabolically active tissues like the liver and heart, Tmem235 activation might be closely tied to metabolic pathways. Chemicals that modulate metabolic signaling, such as those influencing AMPK or PPAR-gamma pathways, could therefore indirectly affect Tmem235 activity. Additionally, its presence in the brain and gut suggests a possible role in neural and gastrointestinal functions, which could be influenced by epigenetic modulators or compounds affecting neurotransmitter systems. Considering the broad expression of Tmem235, its activation could also be linked to cellular stress responses, particularly oxidative stress, common in heart and liver tissues. Compounds with antioxidant properties or those modulating the Nrf2 pathway could potentially impact Tmem235 activity.
In conclusion, the activation of Tmem235 appears to be a multifaceted process, potentially influenced by a variety of biochemical and cellular pathways. While direct activators of Tmem235 are not clearly defined, its involvement in key physiological processes in various organs suggests that its regulation is likely complex and interconnected with multiple signaling pathways. Understanding these pathways and how they can be modulated offers insights into the potential activation mechanisms of Tmem235. This understanding is vital for unraveling the broader implications of Tmem235 in health and disease, particularly in organs where its expression is prominent.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a labdane diterpene, is derived from the roots of Coleus forskohlii. It activates adenylate cyclase, leading to increased levels of cAMP. Elevated cAMP enhances protein kinase A (PKA) activity, which may indirectly upregulate TMEM235 by modulating phosphorylation states of proteins in signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), a catechin found in green tea, inhibits DNA methyltransferases, potentially altering gene expression patterns. This epigenetic modulation could indirectly influence TMEM235 expression by impacting regulatory pathways within the cell, particularly in the brain and gut. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a cytidine analog, incorporates into RNA and DNA, causing demethylation and subsequent transcriptional activation. It may indirectly upregulate TMEM235 by altering the expression of genes that control its transcription or stability, especially in tissues like the liver and heart. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, binds to nuclear receptors influencing gene expression. It may indirectly stimulate TMEM235 expression by regulating genes involved in cellular differentiation and development, particularly in structures like the brain and liver. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, acts as a potent activator of Nrf2, leading to antioxidant response. This activation may indirectly influence TMEM235 expression by modulating oxidative stress pathways, particularly relevant in tissues such as the heart and liver. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a principal curcuminoid of turmeric, exhibits anti-inflammatory properties by inhibiting NF-kB. This inhibition might indirectly enhance TMEM235 expression by modulating inflammatory pathways, especially in organs like the gut and liver, where TMEM235 is expressed. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol in grapes, activates SIRT1, influencing cellular metabolism and longevity pathways. This activation could indirectly upregulate TMEM235 by affecting metabolic processes, particularly in the liver and heart, where TMEM235 is expressed. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, a widely used antidiabetic drug, activates AMP-activated protein kinase (AMPK), influencing cellular energy balance. This activation might indirectly stimulate TMEM235 expression through metabolic pathways, notably in the liver, a key organ in metabolic regulation. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a thiazolidinedione, acts as a PPAR-gamma agonist, influencing lipid metabolism and insulin sensitivity. Its action may indirectly upregulate TMEM235 in tissues like the liver and adipose, where PPAR-gamma is active and TMEM235 is expressed. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, exhibits antioxidant and anti-inflammatory effects. It may indirectly activate TMEM235 by modulating stress response pathways, especially in organs like the heart and liver, where oxidative stress is significant. | ||||||