CLAP Activators
CLAP Activators encompass a group of chemical compounds that indirectly promote the activation of the CLAP protein through various intracellular signaling mechanisms. Forskolin and IBMX, by increasing intracellular cAMP levels, indirectly promote the activation of protein kinase A (PKA), which in turn can phosphorylate and enhance the activity of CLAP. Epigallocatechin Gallate (EGCG) and Genistein operate by inhibiting protein kinases, which otherwise negatively regulate proteins that interact with CLAP, thereby promoting CLAP's functional role. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which phosphorylates several proteins within signaling pathways that intersect with CLAP, leading to its enhanced activation. Moreover, sphingosine-1-phosphate (S1P), by binding to its receptors, initiates a cascade enhancing CLAP activation within its implicated signaling pathways.
Additionally, the activity of CLAP is influenced by kinase inhibitors such as LY294002 and U0126, which inhibit the PI3K/Akt and MEK1/2 pathways, respectively. This inhibition relieves negative regulation on pathways leading to CLAP activation, enhancing its activity. A23187 (Calcimycin) increases intracellular calcium, activating calcium-dependent kinases that can then enhance CLAP activation. Piceatannol, SB203580, and PD 98059 modulate the activity of Syk kinase, p38 MAP kinase, and MEK, respectively. These inhibitors can reduce inhibitory signaling, potentially enhancing activation pathways of CLAP, thereby contributing to the protein's functional upregulation without directly affecting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin targets adenylate cyclase, enhancing its ability to produce cyclic AMP (cAMP). Elevated levels of cAMP lead to the activation of protein kinase A (PKA), which can phosphorylate CLAP, thus leading to its enhanced functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes responsible for the breakdown of cAMP. By preventing cAMP degradation, IBMX indirectly increases the activity of PKA, which in turn can enhance the activity of CLAP by phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases. By inhibiting competitive signaling pathways, EGCG can skew the cellular signaling balance towards pathways that directly activate CLAP. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in a multitude of signaling pathways. PKC activation can lead to the phosphorylation of substrates that directly interact with or activate CLAP. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) is involved in the sphingolipid signaling pathway. S1P can bind to its receptors, initiating a cascade that ultimately leads to the activation of downstream proteins including CLAP. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway. By inhibiting this pathway, LY294002 can decrease the negative regulation imposed on pathways that directly activate CLAP, leading to its enhanced activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases and signaling pathways that directly enhance the activity of CLAP. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits the activation of Syk kinase, which could lead to the modulation of secondary signaling pathways positively influencing the activation of CLAP. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which can prevent the phosphorylation and activation of proteins that negatively regulate CLAP, thus enhancing the functional activity of CLAP. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP Kinase inhibitor, which may reduce regulatory constraints on signaling pathways that activate CLAP, allowing for its enhanced activity. | ||||||