CIS Activators
CIS activators constitute a specialized class of chemical compounds or molecules that play a crucial role in the regulation of cellular signaling pathways, particularly those involved in immune responses and cytokine signaling. CIS, also known as cytokine-inducible SH2-containing protein, is a key component of the negative feedback mechanisms that control immune and inflammatory processes. CIS is part of the suppressor of cytokine signaling (SOCS) family, which includes proteins involved in modulating cytokine signaling by inhibiting the activity of various signaling molecules such as JAK kinases and STAT transcription factors.
CIS activators act by enhancing the expression or activity of CIS itself. When CIS is upregulated or its activity is increased, it serves as a negative regulator of cytokine signaling pathways. This, in turn, dampens the cellular responses to cytokines, preventing excessive inflammation and immune activation. By promoting CIS function, CIS activators help maintain the delicate balance between immune activation and immune suppression, ensuring that the immune system responds appropriately to threats while avoiding harmful overreactions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $156.00 $339.00 | 59 | |
JAK Inhibitor I targets Janus kinases, which are key components of the cytokine signaling pathway. Inhibition of JAKs can indirectly influence CIS function, as CIS is involved in the negative regulation of this pathway. | ||||||
Baricitinib | 1187594-09-7 | sc-364730 sc-364730A | 5 mg 25 mg | $200.00 $664.00 | ||
Baricitinib selectively inhibits JAK1 and JAK2. This modulation of JAK signaling can have an indirect impact on CIS activity in the cytokine signaling pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to affect multiple signaling pathways, including those related to cytokine signaling. Its broad effects could potentially influence CIS activity indirectly. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Stattic is known as an inhibitor of STAT3, a transcription factor downstream of cytokine signaling. Inhibition of STAT3 might indirectly influence CIS regulation. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide is an anthelmintic drug that has been shown to have multiple effects on cellular signaling pathways, potentially affecting CIS activity indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, impacts numerous signaling pathways and may have an indirect effect on CIS, particularly in cytokine-mediated responses. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 is an inhibitor of JAK2 and STAT3. By targeting these components of the cytokine signaling pathway, it can indirectly affect CIS function. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is a JAK2 inhibitor, which can lead to altered cytokine signaling, potentially impacting CIS activity. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | $151.00 | 104 | |
S3I-201 is a selective inhibitor of STAT3. Given CIS's role in cytokine signaling, modulation of STAT3 could indirectly influence CIS function. | ||||||