CIB3 Inhibitors
CIB3 Inhibitors encompass a range of chemical compounds that indirectly inhibit the functional activity of the calcium and integrin-binding family member 3 (CIB3) protein. These compounds are not CIB3 inhibitors themselves but are involved in various cellular signaling pathways and processes that CIB3 may be a part of.
For instance, Wortmannin and LY294002, as PI3K inhibitors, prevent the phosphorylation of AKT, a serine/threonine-specific protein kinase that playsa crucial role in the PI3K/AKT/mTOR signaling pathway. This pathway is integral for processes such as cell growth, survival, metabolism, and proliferation. If CIB3 is involved in this pathway or its activity is modulated by AKT, the inhibition of PI3K and subsequent reduction in AKT phosphorylation by compounds like Wortmannin and LY294002 could result in decreased CIB3 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi that acts as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it blocks the PI3K/AKT pathway which is crucial for cell survival and proliferation. If CIB3 is involved in cell survival signals, wortmannin's action would lead to reduced CIB3 activity due to diminished survival signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a synthetic molecule that inhibits PI3K, leading to suppressed AKT phosphorylation and signaling. Since CIB3 may be associated with growth and survival pathways, the inhibition of PI3K/AKT signaling by LY294002 would consequently decrease CIB3-mediated processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a macrolide compound that inhibits mTOR (mammalian target of rapamycin) by binding to FKBP12. The mTOR pathway is involved in protein synthesis and cell growth. Inhibition of mTOR by rapamycin could reduce CIB3 activity if CIB3 is part of the mTOR signaling cascade that promotes cell growth and proliferation. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is a specific inhibitor of the AKT signaling pathway. It prevents AKT activation and blocks downstream signaling. If CIB3 functions downstream of AKT, triciribine inhibition of AKT would lead to a decrease in CIB3 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase that acts upstream of ERK in the MAPK pathway. This inhibition blocks ERK activation, which is often involved in cell proliferation and survival. If CIB3 operates within this pathway, U0126-mediated blockade would reduce CIB3 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. Inhibition of p38 has been shown to affect cell cycle regulation and apoptosis. If CIB3 activity is related to p38 signaling, SB203580 would lead to diminished CIB3 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), which is implicated in stress responses, apoptosis, and cell differentiation. JNK inhibition by SP600125 would lead to decreased CIB3 activity if CIB3 is part of the JNK signaling pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which, like U0126, prevents the activation of the ERK pathway. By inhibiting MEK, PD98059 would lead to reduced activity of CIB3 if CIB3 is involved in the ERK signaling pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases are involved in various signaling pathways that control cell proliferation, differentiation, and survival. PP2 inhibition of Src could reduce CIB3 activity if CIB3 is associated with Src-mediated signaling. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor. By blocking EGFR signaling, it affects cell proliferation and survival. If CIB3 is part of the EGFR signaling pathway, then inhibition by gefitinib would result in decreased CIB3 activity. | ||||||