CHMP1B Activators
CHMP1B Activators are a suite of chemical compounds that indirectly amplify the functionality of CHMP1B through distinct cellular and signaling mechanisms. Forskolin targets adenylate cyclase to raise intracellular cAMP, which in turn activates PKA, potentially leading to phosphorylation events that bolster CHMP1B's involvement in endosomal sorting. IBMX, by inhibiting the degradation of cAMP, sustains the activation of PKA, which could similarly enhance CHMP1B function. PMA acts through PKC activation, which might impact CHMP1B by modifying the phosphorylation state of proteins within its functional complex, while Ionomycin, by raising intracellular calcium, could activate calmodulin-dependent kinases that intersect with CHMP1B's sorting pathway. Additionally, EGCG and S1P, by inhibiting competitive kinases and signaling through lipid receptors respectively, may clear the way for CHMP1B to more effectively participate in vesicle trafficking.
The action of LY294002 and U0126 as inhibitors of PI3K and MEK, respectively, may shift cellular signaling dynamics to favor CHMP1B's role in the formation and function of multivesicular bodies by altering the activity of intersecting regulatory proteins. Thapsigargin, by disrupting calcium stores, potentially triggers signaling cascades that enhance CHMP1B-related processes. Staurosporine's broad kinase inhibition spectrum might indirectly upregulate CHMP1B by reducing the inhibition of CHMP1B-associated pathways. Finally, NMN, by contributing to NAD+ biosynthesis, indirectly supports sirtuin function, which may deacetylate and thus alter the activity of proteins that interact with CHMP1B, enhancing its role in endosomal sorting and trafficking. Collectively, these activators, through their targeted biochemical actions, foster an environment that facilitates the enhanced functional activity of CHMP1B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in intracellular cAMP levels. The elevated cAMP activates PKA (protein kinase A), which can phosphorylate various proteins that may interact with or regulate CHMP1B function, enhancing its activity in endosomal sorting. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. The resulting increase in cAMP/cGMP can enhance PKA/PKG pathways that could phosphorylate proteins associated with CHMP1B, indirectly enhancing its function in the ESCRT-III complex. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may influence CHMP1B activity by phosphorylating substrates that interact with or modulate CHMP1B's role in membrane remodeling and vesicle trafficking. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
All-trans Retinoic Acid, a metabolite of Vitamin A, modulates cellular differentiation and growth. Although not directly activating CHMP1B, it can alter cellular contexts in which CHMP1B's endosomal sorting function becomes more critical, thus indirectly enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which may impact CHMP1B activity by modulating proteins that are part of the endosomal sorting machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is a catechin found in green tea with various biological effects. It inhibits certain kinases and enzymes that, when inhibited, may reduce competitive signaling pathways, potentially allowing CHMP1B to function more effectively in vesicle formation and trafficking. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors, which can lead to actin cytoskeleton rearrangements. This may enhance CHMP1B's role in membrane scission events during endosomal sorting. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that by inhibiting PI3K, can shift signaling pathways in a way that may favor those regulating or interacting with CHMP1B, indirectly enhancing its role in the formation of multivesicular bodies (MVBs). | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium homeostasis. This can lead to activation of signal transduction pathways influencing proteins that work with CHMP1B in endosomal sorting. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that may indirectly enhance CHMP1B function by inhibiting kinases that negatively regulate proteins associated with CHMP1B's role in vesicle trafficking and membrane scission. | ||||||