CHCHD8 Inhibitors
CHCHD8 inhibitors, while not directly targeting the protein, act by disrupting various cellular processes that CHCHD8 depends on for its proper functioning. One of the key mechanisms through which these chemicals act is by impairing mitochondrial function, either through direct inhibition of the electron transport chain components, as seen with rotenone, antimycin A, and sodium azide, or by disrupting the mitochondrial membrane potential and ATP synthesis, as with oligomycin and CCCP. These compounds effectively decrease the energy production within the mitochondria, which is crucial for the maintenance of mitochondrial integrity and function-a process that CHCHD8 is closely associated with.
Furthermore, other compounds like 2-deoxy-D-glucose and paraquat impose metabolic stress either by inhibiting glycolysis or by inducing oxidative stress, respectively. This metabolic stress can have downstream effects on mitochondrial health, thereby affecting CHCHD8 function. Compounds such as tunicamycin and brefeldin A interfere with protein modification and trafficking, essential processes for mitochondrial protein homeostasis, which can indirectly impact CHCHD8's role in these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting this complex, rotenone leads to reduced ATP production and increased oxidative stress. Since CHCHD8 is involved in mitochondrial function and biogenesis, the decreased ATP levels and oxidative stress can impair the proper functioning of CHCHD8. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin is an inhibitor of the mitochondrial ATP synthase (complex V). It blocks the proton channel, which is essential for ATP synthesis. This inhibition leads to decreased ATP levels that can compromise mitochondrial function, potentially impairing CHCHD8's role in this context. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A is an inhibitor of complex III in the mitochondrial electron transport chain. This inhibition can lead to reduced electron flow through the chain, disrupting mitochondrial membrane potential and energy production, which can in turn negatively influence CHCHD8’s mitochondrial function. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP is a protonophore that collapses the proton gradient across the mitochondrial membrane, disrupting ATP synthesis. The resulting energy depletion can indirectly inhibit CHCHD8 by compromising the energy-dependent processes it is involved in. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain, preventing electron transfer and reducing ATP production. This can indirectly impair the function of CHCHD8 by limiting the energy supply required for its activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glycolysis inhibitor that interferes with glucose metabolism, reducing ATP production. This energy stress can impair mitochondrial function, potentially leading to reduced CHCHD8 activity due to its dependency on mitochondrial integrity. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat is a redox cycling agent that increases reactive oxygen species (ROS) production, leading to oxidative damage. As CHCHD8 is implicated in mitochondrial health, the increased oxidative stress can indirectly inhibit its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation in the endoplasmic reticulum. As certain mitochondrial proteins undergo modifications that are essential for their proper function, the inhibition of glycosylation can affect mitochondrial processes that CHCHD8 is a part of. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the function of the Golgi apparatus, which is involved in protein sorting and trafficking. The disruption can indirectly affect mitochondrial protein homeostasis, thereby potentially impairing CHCHD8 function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels. Elevated cytosolic calcium can induce mitochondrial calcium uptake, which may impair mitochondrial function and thus inhibit CHCHD8's activity. | ||||||