CHCHD8 Activators
CHCHD8 include various compounds that engage with mitochondrial function and biogenesis. Coenzyme Q10 is integral to the electron transport chain, enhancing mitochondrial oxidative phosphorylation, which in turn can increase CHCHD8 activity. Similarly, Methylene Blue serves as an alternative electron carrier within the electron transport chain, supporting the stabilization of mitochondrial function and potentially elevating the function of CHCHD8. Nicotinamide adenine dinucleotide (NAD+) contributes to redox reactions and the operation of sirtuins and PARPs that are crucial for mitochondrial upkeep, which can enhance CHCHD8 activity. Moreover, Resveratrol, by activating sirtuins, particularly SIRT1, may improve mitochondrial health and CHCHD8 activity through the regulation of mitochondrial biogenesis.
Spermidine promotes autophagy, a process that can include the renewal of mitochondria, thus supporting mitochondrial turnover and CHCHD8 activity. Pyrroloquinoline quinone (PQQ) is known to encourage the formation of new mitochondria, indirectly supporting CHCHD8 activity. Alpha-lipoic acid and Retinoic acid both play a role in mitochondrial metabolism and gene expression for mitochondrial function, respectively, which can support CHCHD8 activity. Sulforaphane activates the Nrf2 pathway, which helps maintain mitochondrial integrity, thus benefiting CHCHD8 function. Carnitine is essential for fatty acid transport into mitochondria for β-oxidation, which enhances mitochondrial function and subsequently CHCHD8 activity. Tauroursodeoxycholic acid (TUDCA) maintains mitochondrial health, which can indirectly boost the activity of CHCHD8. Lastly, Melatonin regulates mitochondrial biogenesis, dynamics, and overall function, thereby promoting the activity of CHCHD8 within the cellular powerhouse.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 participates in the mitochondrial electron transport chain, which is vital for energy production. CHCHD8 is located in the mitochondria and is involved in mitochondrial function and cristae structure. Coenzyme Q10 enhances mitochondrial oxidative phosphorylation, which could increase the activity of mitochondrial proteins including CHCHD8. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy, a cellular process that can involve mitochondrial renewal. Through autophagy induction, spermidine may promote the turnover and proper functioning of mitochondria, thereby potentially enhancing the activity of mitochondrial proteins like CHCHD8. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene Blue acts as an alternative electron carrier in the mitochondrial electron transport chain, potentially bypassing dysfunctional components. This could lead to a stabilization of mitochondrial function and an increase in the activity of proteins, such as CHCHD8, that are critical for mitochondrial integrity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme in redox reactions and a substrate for sirtuins and PARPs, which are involved in mitochondrial maintenance. By supporting mitochondrial function, NAD+ may enhance the activity of mitochondrial proteins like CHCHD8. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, particularly SIRT1, which has been implicated in the regulation of mitochondrial biogenesis and function. Through this activation, resveratrol could lead to an improvement in mitochondrial health and thereby increase the activity of mitochondrial proteins including CHCHD8. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $243.00 | ||
PQQ has been shown to support mitochondrial biogenesis. By promoting the formation of new mitochondria, PQQ could indirectly enhance the activity of mitochondrial proteins such as CHCHD8. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is involved in mitochondrial dehydrogenase reactions and can influence mitochondrial metabolism. Through its roles in mitochondrial function, it could support the activity of CHCHD8. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression for mitochondrial function and has been shown to affect mitochondrial biogenesis. Improved mitochondrial function and biogenesis could lead to enhanced activity of mitochondrial proteins like CHCHD8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which regulates the expression of antioxidant proteins that protect against mitochondrial damage. This activation could benefit mitochondrial function and thus the activity of proteins such as CHCHD8. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a bile acid that has been shown to support mitochondrial integrity and function. By maintaining mitochondrial health, TUDCA could indirectly enhance the activity of mitochondrial proteins including CHCHD8. | ||||||