cGAS Antibodies

Santa Cruz Biotechnology delivers a wide array of cGAS Antibodies for research focused on understanding the cGAS pathway and its role in cellular responses to cytosolic DNA. cGAS Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA).Cyclic GMP-AMP synthase (cGAS) is a crucial enzyme that detects cytosolic DNA and initiates an immune response by producing cyclic GMP-AMP (cGAMP), which activates the STING pathway. The cGAS-STING pathway plays a significant role in the innate immune response, influencing inflammation and the development of autoimmune diseases. Understanding cGAS function is vital for developing therapeutic strategies against various diseases, including cancer and viral infections. Research has shown that cGAS activation triggers multiple downstream signaling cascades, leading to the production of type I interferons and other inflammatory mediators. Recent studies have highlighted the importance of cGAS in maintaining cellular homeostasis and preventing the development of various pathological conditions. Investigating cGAS mechanisms has revealed new insights into DNA sensing and immune system regulation. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance their understanding of cGAS biology and its impact on human health.