Gas8 Antibody (E-11): sc-393638

Gas8 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects Gas8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gas8, also known as growth arrest-specific 8, is a 478 amino acid protein that plays a crucial role as a cytoskeletal linker, binding to microtubules and influencing the regulation of axonemal and non-axonemal dyneins, which are essential for cellular motility and structure. Gas8 is predominantly expressed in the liver, heart, and skeletal muscle, with lower expression levels found in the lung, brain, kidney, and placenta. Gas8 localization to the Golgi apparatus, cytoplasm, and flagellar basal body suggests involvement in various cellular processes, including sperm motility, where Gas8 defects may lead to male infertility due to impaired gametocyte function. Furthermore, the gene encoding Gas8 is located on human chromosome 16, a region often deleted in breast and prostate cancers, indicating potential role in tumorigenesis. anti-Gas8 antibody (E-11) is an invaluable tool for researchers studying the intricate functions of Gas8 in both normal physiology and disease states.

The preferred Gas8 antibody is Gas8 Antibody (G-12): sc-390346.