Gas8 Antibody (G-12): sc-390346
- Gas8 Antibody (G-12) is a mouse monoclonal IgG1 κ Gas8 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 55-66 near the N-terminus of Gas8 of human origin
- Gas8 Antibody (G-12) is recommended for detection of Gas8 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-Gas8 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Gas8 Antibody (G-12) for WB applications. These reagents are now offered in bundles with Gas8 Antibody (G-12) (see ordering information below).
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Gas8 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Gas8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gas8 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gas8 protein, also known as growth arrest-specific 8 or Gas11, is a 478 amino acid protein that plays a crucial role in cellular processes by localizing to the Golgi apparatus, cytoplasm, and flagellar basal body. Such localization enables Gas8 to function as a cytoskeletal linker, binding to microtubules and potentially regulating dynein activity, which is essential for cellular motility and division. Gas8 is predominantly expressed in liver, heart, and skeletal muscle, with lower expression levels in lung, brain, kidney, and placenta. Gas8′s involvement in spermatozoa motility highlights its importance in male fertility, as defects in Gas8 may lead to infertility in males lacking gametocytes. Additionally, Gas8′s encoding gene is located on human chromosome 16, a region often deleted in breast and prostate cancers, suggesting a potential role in tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Gas8 Antibody (G-12) References:
- Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. | Yeh, SD., et al. 2002. J Biol Chem. 277: 6311-7. PMID: 11751847
- Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. | Colantonio, JR., et al. 2006. Traffic. 7: 538-48. PMID: 16643277
- Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. | Ralston, KS. and Hill, KL. 2006. PLoS Pathog. 2: e101. PMID: 17009870
- Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. | Bekker, JM., et al. 2007. Cell Motil Cytoskeleton. 64: 461-73. PMID: 17366626
- Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells. | Nishimura, N., et al. 2008. Arch Biochem Biophys. 474: 136-42. PMID: 18396146
- The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. | Colantonio, JR., et al. 2009. Nature. 457: 205-9. PMID: 19043402
- Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. | Whitmore, SA., et al. 1998. Genomics. 52: 325-31. PMID: 9790751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gas8 Antibody (G-12) | sc-390346 | 200 µg/ml | $322.00 | |||
Gas8 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-530130 | 200 µg Ab; 10 µg BP | $361.00 | |||
Gas8 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-523500 | 200 µg Ab, 40 µg BP | $361.00 | |||
Gas8 Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-543883 | 200 µg Ab; 20 µg BP | $361.00 | |||
Gas8 Antibody (G-12) AC | sc-390346 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Gas8 Antibody (G-12) HRP | sc-390346 HRP | 200 µg/ml | $322.00 | |||
Gas8 Antibody (G-12) FITC | sc-390346 FITC | 200 µg/ml | $336.00 | |||
Gas8 Antibody (G-12) PE | sc-390346 PE | 200 µg/ml | $349.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 488 | sc-390346 AF488 | 200 µg/ml | $364.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 546 | sc-390346 AF546 | 200 µg/ml | $364.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 594 | sc-390346 AF594 | 200 µg/ml | $364.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 647 | sc-390346 AF647 | 200 µg/ml | $364.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 680 | sc-390346 AF680 | 200 µg/ml | $364.00 | |||
Gas8 Antibody (G-12) Alexa Fluor® 790 | sc-390346 AF790 | 200 µg/ml | $364.00 | |||
Gas8 (G-12) Neutralizing Peptide | sc-390346 P | 100 µg/0.5 ml | $69.00 |