Gas7 Antibody (B-4): sc-376955

Gas7 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects Gas7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Gas7 is a critical growth arrest-specific protein that plays a significant role in neurite differentiation, particularly in cultured mouse cerebellar neurons and PC-12 cells, highlighting Gas7′s potential as a therapeutic target for promoting neuronal connection re-establishment in injured or diseased brains. Gas7 is expressed in three isoforms—Gas7a, Gas7b, and Gas7c—which exhibit differential expression across various brain subregions, underscoring the complexity of Gas7′s function in neurodevelopment and repair. Additionally, the gene encoding human Gas7 is located on chromosome 17p13.1, where Gas7 can translocate with the MLL gene to form MLL-GAS7 fusion products, which may have implications in certain hematological malignancies. Gas7′s ability to interact with specific proteins involved in neuronal signaling pathways further emphasizes Gas7′s importance in neurobiology and potential as a biomarker for neurological conditions. anti-Gas7 antibody (B-4) is an essential tool for researchers investigating the mechanisms of neuronal differentiation and the therapeutic avenues for neurodegenerative diseases.

The preferred Gas7 antibody is Gas7 Antibody (H-9): sc-365385.