CEP78 Activators

Forskolin, by raising intracellular cAMP levels, activates protein kinase A, which may phosphorylate substrates relevant to CEP78's role in the cell. Retinoic acid, through its gene regulatory actions, potentially upregulates proteins that could interact with CEP78, facilitating its function in ciliogenesis. Lithium chloride, a GSK-3 inhibitor, and MG132, a proteasome inhibitor, both contribute to the modulation of protein stability and expression that can reflect on CEP78's activity. Roscovitine, by inhibiting cyclin-dependent kinases, affects cell cycle progression, which is closely tied to the centrosomal function where CEP78 is localized. Similarly, the Aurora kinase inhibitor ZM447439 may alter the phosphorylation state of centrosomal proteins, which can have downstream effects on CEP78's role within the centrosome.

The action of 5-Azacytidine as a DNA methyltransferase inhibitor may lead to changes in the expression of genes encoding proteins that interact with CEP78, influencing its function. SB431542, which inhibits TGF-β receptors, and PD98059, a MEK inhibitor, both have the capacity to alter signaling pathways that are crucial for centrosome and cilia maintenance, potentially affecting CEP78. Rapamycin, an mTOR inhibitor, impacts protein synthesis and cell growth, which can indirectly modulate the assembly and function of centrosomal proteins, including CEP78. Brefeldin A disrupts the ER to Golgi protein transport, potentially influencing the processing and trafficking of proteins that associate with CEP78. Nocodazole's disruption of microtubule dynamics can affect the centrosome's integrity and, consequently, CEP78's activity in centrosomal maintenance.