CEP27 Activators
CEP27 activators are a class of chemical compounds that interact with the cellular machinery at a molecular level, specifically targeting a protein known as CEP27. The role of CEP27 within the cellular environment is crucial for maintaining certain aspects of cellular function, although the detailed mechanisms may be highly complex and not fully elucidated. These activators bind to CEP27 or influence its activation state, which in turn can lead to a cascade of cellular events. The specificity of CEP27 activators lies in their ability to modulate this protein's activity, which requires a nuanced understanding of the protein's structure and the intracellular pathways it is involved in. The design of these molecules takes into account the precise conformation of CEP27, ensuring that the interaction between the activator and the target protein is both effective and precise.
The chemistry underlying CEP27 activators is often rooted in the principles of molecular recognition, which involves the careful design of small molecules to achieve a high affinity and specificity for the protein target. This requires a deep understanding of the structure-activity relationship (SAR), which delineates how various chemical modifications to the molecule can impact its ability to activate CEP27. Typically, these activators are the product of extensive medicinal chemistry efforts that involve iterative cycles of design, synthesis, and testing to optimize their interaction with the protein. The molecular frameworks of CEP27 activators can vary widely, from small organic molecules to larger, more complex structures, depending on the nature of the interaction with CEP27 and the specific cellular context in which they operate. The development of these compounds relies heavily on techniques such as X-ray crystallography, NMR spectroscopy, and computational modeling to visualize and predict the interaction with the target protein, aiming to achieve selectivity and proper engagement with the CEP27 protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased production of cyclic AMP (cAMP), which can activate protein kinase A (PKA). PKA can phosphorylate various target proteins, which may include CEP27 or its interacting partners, leading to enhanced functional activity of CEP27 in the centrosome cycle. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates involved in centrosome duplication and maturation. This phosphorylation could indirectly enhance the functional activity of CEP27 by promoting the centrosome cycle. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, which could lead to increased phosphorylation levels of proteins within the centrosome cycle. The inhibition of dephosphorylation could thus indirectly enhance the activity of CEP27 within the centrosome. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits protein phosphatases such as PP1 and PP2A. The resulting increase in phosphorylation of proteins associated with centrosome function could indirectly enhance the activity of CEP27 by promoting centrosome assembly and disassembly processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of ubiquitinated proteins. By stabilizing proteins that regulate the centrosome cycle, MG132 could indirectly enhance the functional activity of CEP27 by maintaining a cellular environment conducive to centrosome assembly, which CEP27 is involved in. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to stabilization of microtubule-associated proteins, which could support the functions of CEP27 in centrosome and microtubule organization. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor which can lead to DNA demethylation. This process can result in the expression of genes associated with the centrosome cycle, potentially enhancing the activity of CEP27 through increased interaction with other centrosomal proteins. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase (CDK) inhibitor. By inhibiting CDKs, Roscovitine could indirectly enhance CEP27 activity by affecting the timing and regulation of the centrosome cycle, in which CDKs play a critical role. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. Inhibition of Aurora kinases could lead to altered dynamics of centrosome function, indirectly affecting the role of CEP27 in centrosome maturation and separation, potentially enhancing its activity by modulating these processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can lead to the arrest of the cell cycle at the G2/M phase. This stabilization may enhance the role of CEP27 in organizing microtubules at the centrosome and could indirectly enhance its functional activity during cell division. | ||||||