CEP152 Activators
CEP152 activators are chemical compounds that enhance the activity of CEP152, a protein that plays a crucial role in centrosome duplication and positioning. These activators exert their influence by affecting specific cellular processes and signaling pathways that CEP152 is directly involved in. For instance, A23187 and Taxol enhance CEP152 function by affecting calcium levels and microtubule stability, respectively. Nocodazole also enhances CEP152 function by disrupting microtubules, thereby enhancing CEP152's role in rebuilding the microtubule network.
Moreover, Calyculin A and Okadaic Acid enhance CEP152 function by inhibiting protein phosphatases PP1 and PP2A, thereby affecting the phosphorylation status of proteins involved in centrosome duplication. MG132 enhances CEP152 function by raising overall protein levels in the cell. Bafilomycin A1 and Dynasore enhance CEP152 function by affecting endosomal trafficking and endocytosis, respectively, processes in which CEP152 is directly involved. Epothilone B,like Taxol, enhances CEP152 function by stabilizing microtubules. Colchicine enhances CEP152 function by disrupting microtubules, which leads to the recruitment of CEP152 to the centrosome to aid in rebuilding the microtubule network. Last but not least, Cytochalasin D and Jasplakinolide enhance CEP152 function by influencing actin polymerization, a process that CEP152 interacts with during centrosome positioning.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels. CEP152 interacts with proteins affected by calcium levels. An increase in calcium promotes microtubule stabilization, which enhances the function of CEP152, a key player in centrosome duplication. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules by preventing their depolymerization. As CEP152 is involved in centrosome duplication, which is dependent on microtubule stability, Taxol can enhance CEP152 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, which can enhance CEP152 function. When disrupted, CEP152 is recruited to the centrosome to aid in rebuilding the microtubule network, which is crucial for proper centrosome duplication. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). It can enhance CEP152 function by affecting the phosphorylation state of proteins associated with centrosome duplication, a process where CEP152 plays a key role. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, like Calyculin A, is an inhibitor of PP1 and PP2A. It can enhance CEP152 function by influencing the phosphorylation state of proteins involved in centrosome duplication, a process where CEP152 is involved. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can raise the overall levels of proteins in the cell. As CEP152 interacts with various proteins involved in centrosome duplication, higher protein levels can augment CEP152 function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it affects endosomal trafficking, a process that CEP152 is involved in, thereby enhancing the function of CEP152. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits the GTPase activity of dynamin, which is involved in endocytosis, a process that CEP152 is also involved in. Therefore, inhibiting dynamin can enhance the functionality of CEP152 in this process. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules, similar to Taxol. Thus, it can enhance the function of CEP152 in centrosome duplication. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine inhibits microtubule polymerization, which can enhance CEP152 function. CEP152 is recruited to the centrosome to help rebuild the microtubule network when microtubules are disrupted, crucial for centrosome duplication. | ||||||