centlein Activators
Centlein activators are chemical compounds that enhance the activity of centlein, a protein that plays a critical role in microtubule dynamics and other cellular processes. These activators work by influencing specific cellular processes and signaling pathways that centlein is directly involved in. For instance, A23187 and Taxol enhance the function of centlein by affecting the calcium levels and microtubule stability, respectively. Nocodazole also enhances centlein function by disrupting microtubules, which enhances centlein's role in rebuilding the microtubule network.
Moreover, Calyculin A and Okadaic Acid enhance centlein function by inhibiting protein phosphatases 1 and 2A, thereby affecting the phosphorylation status of proteins that interact with centlein. Similarly, MG132 enhances centlein function by increasing the overall protein levels in the cell. Bafilomycin A1 and Dynasore also enhance centlein function by affecting endosomal trafficking and endocytosis, respectively, processes inwhich centlein is directly involved. Epothilone B, similar to Taxol, enhances centlein function by stabilizing microtubules. Colchicine inhibits microtubule polymerization, thereby enhancing centlein's role in microtubule network rebuilding. Furthermore, Cytochalasin D and Jasplakinolide enhance centlein function by influencing the dynamics of the actin cytoskeleton, with which centlein interacts. Cytochalasin D inhibits actin polymerization, while Jasplakinolide promotes it.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Centlein is reported to interact with microtubules, which are affected by calcium levels. Increased calcium can promote microtubule stabilization and thus enhance the function of centlein. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol is a drug that stabilizes microtubules and prevents their depolymerization. Since centlein is known to interact with microtubules, stabilization of microtubules by taxol can enhance the function of centlein. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a compound that disrupts microtubules. When microtubules are disrupted, centlein can be recruited to the centrosome to help rebuild the microtubule network, thereby enhancing its function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). By inhibiting these phosphatases, it can enhance centlein function, as centlein is known to interact with proteins whose phosphorylation status is regulated by these phosphatases. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Similar to Calyculin A, it can enhance centlein function, as centlein can interact with proteins whose phosphorylation status is regulated by these phosphatases. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can increase the overall levels of proteins in the cell. Since centlein is known to interact with various proteins, higher levels of these proteins can enhance centlein function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it can affect endosomal trafficking, a process in which centlein is involved. This can result in the enhanced function of centlein. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a non-competitive inhibitor of the GTPase activity of dynamin. Dynamin is involved in endocytosis, a process that centlein is also involved in. Therefore, inhibiting dynamin can enhance the function of centlein in this process. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B is a microtubule stabilizer, similar to taxol. It can enhance the function of centlein by stabilizing the microtubules that centlein interacts with. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine is a drug that inhibits microtubule polymerization. This can enhance the function of centlein, as it is recruited to the centrosome to help rebuild the microtubule network when microtubules are disrupted. | ||||||