centlein Inhibitors
Chemical inhibitors of centlein target essential processes in cell division, particularly those involving the mitotic spindle and centrosome function, to achieve functional inhibition of the protein. Monastrol, S-Trityl-L-cysteine, and Dimethylenastron disrupt the activity of the kinesin Eg5, which is crucial for spindle polymerization during mitosis. As centlein is implicated in centrosome separation and spindle formation, the inhibition of Eg5 by these chemicals leads to spindle assembly disruption, thereby impeding centlein's role in this critical cell cycle phase. Similarly, Ispinesib, which inhibits kinesin spindle protein (KSP), and VX-680, which targets Aurora kinases, derail spindle dynamics and centrosome cohesion. These actions are instrumental in hindering centlein's associated functions in cell division.
Further, ZM447439 and Hesperadin, which inhibit Aurora kinase A and B respectively, as well as MLN8054 and MLN8237 that specifically target Aurora kinase A, and Barasertib, which is selective for Aurora kinase B, all serve to disrupt processes vital for centrosome maturation and spindle assembly, where centlein plays a key role. By undermining the functions of these kinases, these inhibitors interfere with chromosome alignment and segregation, directly impacting centlein's activity in mitosis. Maribavir, though primarily an inhibitor of the viral UL97 kinase, may exhibit off-target effects that interfere with human kinases involved in the centrosome cycle. Lastly, PHA-680632, which inhibits Aurora kinases A and B, compromises the proper function of the centrosome and spindle microtubules, thereby disrupting centlein's role in these mitotic processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a known inhibitor of the kinesin Eg5, which is vital for spindle polymerization during mitosis. Centlein is implicated in centrosome separation and spindle formation. By inhibiting Eg5, Monastrol can indirectly lead to the disruption of spindle assembly, potentially inhibiting centlein's role in this process. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of the mitotic kinesin Eg5. As centlein is essential for proper centrosome function and spindle fiber assembly, inhibiting Eg5 disrupts proper spindle formation, thus functionally inhibiting centlein's role in the centrosome. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is another Eg5 inhibitor. It works by disrupting the motor domains of Eg5, leading to mitotic arrest. Since centlein is involved in mitotic spindle formation, inhibition of Eg5 can compromise centrosome integrity and function, thus functionally inhibiting centlein. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $505.00 | ||
Ispinesib selectively inhibits kinesin spindle protein (KSP), another component of the mitotic spindle apparatus. By inhibiting KSP, ispinesib can indirectly inhibit centlein's associated functions in spindle dynamics and centrosome cohesion. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
VX-680 (also known as Tozasertib) is an Aurora kinase inhibitor. Aurora kinases are essential for centrosome maturation and separation, processes in which centlein is also involved. By inhibiting Aurora kinases, VX-680 can disrupt centrosome function and indirectly inhibit centlein. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an inhibitor of Aurora kinase A and B, which are involved in the regulation of mitosis. Since centlein is critical for centrosome duplication and spindle assembly, inhibition of Aurora kinases by ZM447439 would functionally inhibit centlein's role in these processes. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin is an inhibitor of Aurora B kinase. By inhibiting Aurora B kinase, Hesperadin may interfere with chromosome alignment and segregation, where centlein plays a role, thereby functionally inhibiting centlein's activity in mitosis. | ||||||
MLN 8054 | 869363-13-3 | sc-484828 | 5 mg | $398.00 | ||
MLN8054 is a selective inhibitor of Aurora kinase A, which is involved in centrosome maturation and spindle assembly. By specifically inhibiting Aurora A, MLN8054 can indirectly disrupt the function of centlein in facilitating centrosome-related activities. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
MLN8237, also known as Alisertib, is an Aurora A kinase inhibitor. By inhibiting this kinase, MLN8237 can disrupt the centrosome cycle and spindle assembly, where centlein is a key player, thus functionally inhibiting centlein. | ||||||