MLN 8054 (CAS 869363-13-3)
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MLN 8054 is a compound of interest within the field of cell biology and biochemistry, primarily studied for its effects on certain cellular proteins. It is often utilized in research to investigate the regulation of cell cycle progression due to its inhibitory action on specific kinases. This action makes it a useful probe for understanding the mechanisms of cell division and proliferation. In molecular biology studies, MLN 8054 serves as a tool to dissect the signaling pathways that govern these fundamental cellular processes. Additionally, its role in the modulation of protein-protein interactions is examined, further contributing to the knowledge of intracellular communication and regulation. In the area of biochemistry, MLN 8054 is used to explore the structure-activity relationships of kinase inhibitors, aiding in the design of compounds with improved selectivity and potency. The compound also finds application in the study of cellular responses to external stimuli that influence growth and survival pathways.
MLN 8054 (CAS 869363-13-3) References
- Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. | Prosser, SL., et al. 2012. J Cell Sci. 125: 5353-68. PMID: 22956538
- Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs. | Uitdehaag, JC., et al. 2015. PLoS One. 10: e0125021. PMID: 26018524
- Spatial Separation of Plk1 Phosphorylation and Activity. | Bruinsma, W., et al. 2015. Front Oncol. 5: 132. PMID: 26114094
- Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells. | Kotak, S., et al. 2016. J Cell Sci. 129: 3015-25. PMID: 27335426
- The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. | Min, YH., et al. 2016. Oncotarget. 7: 84718-84735. PMID: 27713168
- Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines. | Libouban, MAA., et al. 2017. Oncotarget. 8: 38309-38325. PMID: 28415765
- Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP. | Sarkar, S., et al. 2017. Mol Cancer Res. 15: 1063-1072. PMID: 28536143
- Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states. | Lake, EW., et al. 2018. Proc Natl Acad Sci U S A. 115: E11894-E11903. PMID: 30518564
- Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus. | Labonte, AC., et al. 2018. PLoS One. 13: e0208132. PMID: 30562343
- Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds. | Borba, JVB., et al. 2019. Comput Struct Biotechnol J. 17: 352-361. PMID: 30949306
- Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. | Peng, J., et al. 2019. Cell Res. 29: 725-738. PMID: 31273297
- Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. | Allegretti, PA., et al. 2020. Bioorg Med Chem. 28: 115193. PMID: 31757680
- NuMA interaction with chromatin is vital for proper chromosome decondensation at the mitotic exit. | Rajeevan, A., et al. 2020. Mol Biol Cell. 31: 2437-2451. PMID: 32845810
- Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy. | Lee, JY., et al. 2020. Transl Vis Sci Technol. 9: 39. PMID: 32908802
- EZH2 as a prognostic-related biomarker in lung adenocarcinoma correlating with cell cycle and immune infiltrates. | Fan, K., et al. 2023. BMC Bioinformatics. 24: 149. PMID: 37069494
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MLN 8054, 5 mg | sc-484828 | 5 mg | $398.00 |