CENP-R Inhibitors
CENP-R inhibitors, while not directly targeting the protein, function through mechanisms that impede or modulate cell division processes, particularly in kinetochore formation and function. The kinetochore plays a pivotal role in mitosis, ensuring accurate chromosome segregation. Agents like Paclitaxel and Nocodazole, which influence microtubule dynamics, have the potential to disrupt kinetochore attachment, subsequently impacting the cellular role of CENP-R. This is a clear representation of the interdependence between microtubules and kinetochore proteins, where disruption in one component can resonate through the entire mitotic apparatus.
Moreover, kinases like Aurora kinases and Polo-like kinase 1 (Plk1) are integral to mitosis. Their inhibition, by compounds such as ZM447439, Hesperadin, and BI 2536, can indirectly modulate CENP-R's function within the kinetochore. For instance, Aurora B kinase ensures accurate kinetochore-microtubule attachment, and its inhibition might shift the kinetochore's protein dynamics, including CENP-R's role.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, preventing their disassembly. Can indirectly affect CENP-R function by disrupting kinetochore attachment. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules, hindering spindle formation. By affecting microtubule dynamics, it can indirectly influence CENP-R. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Inhibits Aurora kinases, crucial for centrosome maturation and spindle assembly, potentially influencing CENP-R's kinetochore function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Kinesin-5 (Eg5) inhibitor. By inhibiting mitotic spindle formation, it can affect processes that CENP-R is involved in. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Inhibits Polo-like kinase 1 (Plk1), which is vital for proper mitotic progression, possibly modulating CENP-R's kinetochore function. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Aurora B kinase inhibitor. By disrupting proper chromosome alignment and segregation, it can affect CENP-R's function indirectly. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Aurora kinase inhibitor. Impacts kinetochore-microtubule attachment, potentially influencing CENP-R's role in mitosis. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Cyclin-dependent kinase (CDK) inhibitor. As CDKs regulate cell cycle progression, they may influence processes CENP-R is involved in. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $221.00 | 13 | |
A kinase inhibitor which affects various cell cycle kinases. This broad-spectrum inhibition can indirectly modulate CENP-R function. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Dihydrofolate reductase inhibitor. By blocking DNA synthesis, it can affect cell division processes where CENP-R is operational. | ||||||