CENP-R Activators
The chemical class termed CENP-R Activators consists of a range of compounds primarily characterized by their ability to modify epigenetic markers and chromatin architecture, which in turn can lead to the enhanced expression of CENP-R. The compounds listed above are known to act on various molecular targets such as DNA methylation, histone acetylation, and chromatin compaction, which are fundamental processes governing gene expression.
In the context of CENP-R, these compounds primarily function by remodeling the chromatin landscape around the centromeric regions where CENP-R is located, either by inhibiting the enzymes responsible for maintaining a repressive chromatin environment or by actively promoting a transcriptionally favorable chromatin state. For instance, histone deacetylase inhibitors like Trichostatin A, Vorinostat, Sodium butyrate, and Valproic acid lead to an accumulation of acetylated histones, associated with an open chromatin conformation and active gene expression. Similarly, compounds like 5-Aza-2'-deoxycytidine and Decitabine induce DNA hypomethylation, which can activate the transcription of genes that are otherwise silenced by DNA methylation
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea that has been shown to affect DNA methylation patterns, which could indirectly influence the expression of CENP-R by altering the methylation status of its promoter region. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can change chromatin structure and gene expression; it may enhance the transcription of CENP-R by increasing acetylation levels of histones near its genomic locus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can lead to the hypomethylation of DNA and subsequently affect gene expression, possibly upregulating CENP-R expression by demethylating its promoter. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor that could indirectly increase CENP-R expression by promoting a more open chromatin state in the centromeric region, allowing for the transcriptional machinery to access the CENP-R gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound which may modulate sirtuin activity, influencing chromatin and potentially increasing the expression of centromere-associated proteins such as CENP-R by altering chromatin compaction. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor that promotes histone hyperacetylation, potentially affecting CENP-R expression by changing the chromatin dynamics around its genomic locus, thereby affecting its transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone with epigenetic modulating properties, including DNA methylation and histone acetylation, which could affect the transcriptional regulation of CENP-R. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A involved in gene regulation, which might affect CENP-R expression through modulation of the transcription factors or epigenetic mechanisms. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, known to influence histone deacetylase activity, potentially affecting gene expression patterns of proteins involved in chromosomal segregation, such as CENP-R. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
An HDAC inhibitor that may alter gene expression profiles, including those of centromeric proteins such as CENP-R, by changing the acetylation status of histones and other proteins involved in chromatin structure. | ||||||