CENP-M Activators
CENP-M activators are chemical compounds that enhance the functional activity of CENP-M, a protein involved in the kinetochore complex that plays a critical role in maintaining chromosome alignment during mitosis. These activators work by influencing specific cellular processes and signaling pathways that CENP-M is directly involved in. Compounds such as Nocodazole and Taxol disrupt or stabilize microtubule dynamics, respectively, causing defects in chromosome alignment and thus increasing the demand for CENP-M's role in maintaining chromosome alignment during mitosis. Similarly, Monastrol and S-Trityl-L-cysteine, by inhibiting the motor protein Eg5 necessary for bipolar spindle formation, also increase the demand for CENP-M's function.
Further CENP-M activators function by modulating key kinases or enzymes involved in mitotic spindle assembly and the cell cycle. ZM447439, Hesperadin, and MLN8237 are inhibitors of Aurora kinases, which are critical for mitotic spindle assembly. By inhibiting these kinases, these compounds could enhance the demand for CENP-M's role in maintaining chromosome alignment during mitosis. Similarly, BI2536, a Polo-like kinase 1 (Plk1) inhibitor, can also enhance CENP-M's function by inhibiting Plk1, a regulator of centrosome maturation and spindle assembly. In addition to these, compounds such as Methotrexate and 5-Fluorouracil, which inhibit DNA synthesis and induce replication stress, and Etoposide, a topoisomerase II inhibitor that induces DNA damage, can also increase the demand for CENP-M's role in chromosome alignment during mitosis. Lastly, Roscovitine, a cyclin-dependent kinase inhibitor that can induce cell cycle arrest, can further enhance the functional activity of CENP-M by increasing its importance in maintaining chromosome alignment during a prolonged mitotic phase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a known microtubule depolymerizer. By disrupting microtubule dynamics, it can cause defects in chromosome alignment, which may necessitate the role of CENP-M in maintaining chromosome alignment during mitosis. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol is a microtubule stabilizer. By stabilizing microtubules, it can cause defects in chromosome alignment, which may necessitate the role of CENP-M in maintaining chromosome alignment during mitosis. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is an inhibitor of the motor protein Eg5 which is necessary for bipolar spindle formation. By inhibiting spindle formation, it can place a greater burden on CENP-M's role in maintaining chromosome alignment during mitosis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an ATP-competitive inhibitor of Aurora kinase, which plays a role in the regulation of mitotic spindle assembly. By inhibiting Aurora kinase, it could increase the demand for CENP-M's function in maintaining chromosome alignment during mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI2536 is a potent and selective inhibitor of Polo-like kinase 1 (Plk1), which regulates centrosome maturation and spindle assembly. By inhibiting Plk1, it can increase the demand for CENP-M's function in maintaining chromosome alignment during mitosis. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of the mitotic kinesin Eg5. By inhibiting Eg5, it can increase the demand for CENP-M's role in maintaining chromosome alignment during mitosis. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a folate antagonist that inhibits DNA synthesis. Inhibition of DNA synthesis can cause replication stress, which can increase the demand for CENP-M's role in maintaining chromosome alignment during mitosis. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin is an Aurora B kinase inhibitor. By inhibiting Aurora B, a kinase involved in the regulation of the spindle assembly checkpoint, it could increase the demand for CENP-M's function in maintaining chromosome alignment during mitosis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a nucleotide analogue that inhibits DNA synthesis. By inducing replication stress, it can increase the demand for CENP-M's role in maintaining chromosome alignment during mitosis. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
MLN8237 is an Aurora A kinase inhibitor. By inhibiting Aurora A, it could increase the demand for CENP-M's function in maintaining chromosome alignment during mitosis. | ||||||