CEM15 Inhibitors
CEM15 inhibitors, also known as APOBEC3G inhibitors, belong to a specialized class of small molecules that inhibit CEM15 (Cytidine Deaminase APOBEC3G). CEM15 is a member of the APOBEC (Apolipoprotein B mRNA Editing Catalytic Polypeptide-like) family of proteins, which play essential roles in various cellular processes, including innate immunity and genetic diversity. CEM15, in particular, is involved in the innate immune response against retroviruses, such as HIV-1. It functions by catalyzing the deamination of cytosine residues in single-stranded viral DNA, inducing hypermutations that disrupt the viral genome's integrity and inhibit its replication.
CEM15 inhibitors modulate the activity of CEM15. They typically work by binding to specific sites on the enzyme, preventing it from effectively deaminating cytosine residues in the viral DNA. By inhibiting CEM15, these molecules interfere with the host's innate immune defense mechanism, potentially allowing the virus to evade the immune system's surveillance and replicate more efficiently.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound may inhibit DNA methyltransferases, potentially reducing methylation and altering gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-azacytidine, it might incorporate into DNA and affect methylation patterns. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As an HDAC inhibitor, it may alter histone acetylation, influencing gene expression profiles. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Another HDAC inhibitor, potentially altering chromatin structure and gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
It may bind to DNA and interfere with transcription factor binding, altering expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
It may inhibit transcriptional activity via an effect on RNA polymerase II. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Known to intercalate DNA, it may inhibit RNA synthesis and thereby gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
It can inhibit RNA polymerase II, potentially decreasing mRNA synthesis for some genes. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
It has been reported to inhibit DNA methyltransferases without the DNA-damaging effects of nucleoside analogs. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
This compound may inhibit G9a histone methyltransferase, altering chromatin and gene expression. | ||||||