Date published: 2026-3-9

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Cdk5 Inhibitors

Cdk5 inhibitors belong to a class of chemical compounds designed to target and inhibit the activity of cyclin-dependent kinase 5 (Cdk5), an enzyme crucial for regulating cell cycle progression and neuronal development. Cdk5 is a member of the cyclin-dependent kinase family, which plays a central role in governing cell cycle transitions and cellular processes such as transcription, metabolism, and differentiation. Cdk5, while originally identified for its role in neuronal development, has been found to have broader implications in various cellular functions. As a consequence, researchers have explored the development of inhibitors that can modulate its activity. Cdk5 inhibitors are designed with the intention of selectively binding to the active site of the Cdk5 enzyme, thereby preventing its interaction with specific cyclin partners and impairing its ability to phosphorylate target proteins. By disrupting these phosphorylation events, Cdk5 inhibitors can influence cellular processes that rely on proper protein phosphorylation, including signal transduction pathways and gene expression. Structurally diverse, these inhibitors are tailored to fit the active site of Cdk5, aiming to achieve high specificity and affinity for the target enzyme. Researchers have investigated various chemical scaffolds and modifications to optimize binding interactions and inhibitory potency. In conclusion, Cdk5 inhibitors represent a significant category of chemical compounds that hold promise for modulating cellular processes reliant on Cdk5 activity. By selectively interfering with the enzyme's function, these inhibitors contribute to a deeper understanding of the complex regulatory networks in which Cdk5 participates.

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Items 1 to 10 of 39 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$259.00
41
(3)

Flavopiridol (CAS 146426-40-6) is a chemical compound known for its role as a Cdk5 inhibitor. It affects the activity of Cdk5, a crucial protein involved in cellular processes.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$94.00
$265.00
42
(2)

Roscovitine inhibits CDK5 by binding to the ATP-binding pocket, thereby blocking the phosphorylation of CDK5 substrates.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Staurosporine (CAS 62996-74-1) is a compound that acts as a potent inhibitor of Cdk5, a key enzyme involved in cellular processes. It exerts inhibitory effects on Cdk5's function, impacting various cellular pathways.

GSK-3 Inhibitor IX

667463-62-9sc-202634
sc-202634A
sc-202634B
1 mg
10 mg
50 mg
$58.00
$188.00
$884.00
10
(1)

GSK-3 Inhibitor IX (CAS 667463-62-9) is a compound known for its role as a Cdk5 inhibitor. By targeting Cdk5, it modulates cellular processes that rely on this enzyme's activity.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$61.00
$153.00
$231.00
$505.00
1
(1)

Kenpaullone acts as a CDK5 inhibitor by competing with ATP and blocking the catalytic activity of the enzyme.

Purvalanol A

212844-53-6sc-224244
sc-224244A
1 mg
5 mg
$72.00
$297.00
4
(2)

Purvalanol A is a CDK5 inhibitor that competes with ATP for binding to the enzyme, resulting in reduced kinase activity.

Purvalanol B

212844-54-7sc-361300
sc-361300A
10 mg
50 mg
$199.00
$846.00
(1)

Purvalanol B (CAS 212844-54-7) functions as a Cdk5 inhibitor, effectively regulating cellular processes that involve this enzyme. Its inhibitory action on Cdk5 influences various cellular functions.

10Z-Hymenialdisine

82005-12-7sc-360987
500 µg
$210.00
(1)

10Z-Hymenialdisine (CAS 82005-12-7) acts as a Cdk5 inhibitor, modulating crucial cellular processes associated with this enzyme's function. Its role in inhibiting Cdk5 has implications for various cellular activities.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$114.00
$525.00
4
(1)

Indirubin (CAS 479-41-4) functions as a Cdk5 inhibitor, impacting key cellular processes regulated by this enzyme. Its inhibitory role in relation to Cdk5 has broad effects on various cellular functions.

Aminopurvalanol A

220792-57-4sc-223775
sc-223775A
1 mg
5 mg
$51.00
$118.00
(1)

Aminopurvalanol A (CAS 220792-57-4) acts as a Cdk5 inhibitor, influencing essential cellular processes associated with this enzyme. Its inhibitory function in relation to Cdk5 has wide-ranging effects on various cellular activities.