10Z-Hymenialdisine is a novel alkaloid isolated from Axinella damicornis. It is known to act as an ATP-competitive kinase inhibitor. It exhibits inhibitory activity against cyclin-dependent kinases, CK1 and GSK-3β. It has also been shown to block the phospho 10Z-Hymenialdisine is an inhibitor of Cdk1, Cdk2, Cdk3, Cdk5, cyclin A, cyclin B, cyclin E, MEK-1 and p35. 10Z-Hymenialdisine is an inhibitor of MARK.
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