10Z-Hymenialdisine CAS: 82005-12-7
MF: C11H10BrN5O2
MW: 324.13
An ATP competitive, CK1 and GSK-3β inhibitor.

10Z-Hymenialdisine (CAS 82005-12-7)

10Z-Hymenialdisine | CAS 82005-12-7 is rated 5.0 out of 5 by 1.
  • y_2020, m_5, d_27, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_360987, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 137ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: 4Z)-4-(2-Amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
Application: 10Z-Hymenialdisine is an ATP competitive, CK1 and GSK-3β inhibitor
CAS Number: 82005-12-7
Purity: ≥97%
Molecular Weight: 324.13
Molecular Formula: C11H10BrN5O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

10Z-Hymenialdisine is a novel alkaloid isolated from Axinella damicornis. It is known to act as an ATP-competitive kinase inhibitor. It exhibits inhibitory activity against cyclin-dependent kinases, CK1 and GSK-3β. It has also been shown to block the phospho 10Z-Hymenialdisine is an inhibitor of Cdk1, Cdk2, Cdk3, Cdk5, cyclin A, cyclin B, cyclin E, MEK-1 and p35. 10Z-Hymenialdisine is an inhibitor of MARK.


References

1. Supriyono, A., et al. 1995. Z. Naturforsch., C, J. Biosci. 50: 669-674. PMID: 8579685
2. Breton, J.J., et al. 1997. J. Pharmacol. Exp. Ther. 282: 459-466. PMID: 9223588
3. Roshak, A., et al. 1997. J. Pharmacol. Exp. Ther. 283: 955-961. PMID: 9353419
4. Meijer, L., et al. 2000. Chem. Biol. 7: 51-63. PMID: 10662688

Appearance :
Oil
Physical State :
Solid
Derived From :
Axinella carteri
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
273.54° C (Predicted)
Boiling Point :
630.45° C (Predicted)
Density :
~2.2 g/mL (Predicted)
Refractive Index :
n20D 1.91 (Predicted)
IC50 :
ERK2: IC50 = 6 nM (human); MEK-1: IC50 = 6 nM (human); GSK-3β: IC50 = 10 nM (human); Cyclin-dependent kinase 1/cyclin B: IC50 = 22 nM (human); Cyclin-dependent kinase 5/CDK5 activator 1: IC50 = 28 nM (human)
pK Values :
pKa: 13.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UY8427710
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
3036831
MDL Number :
MFCD04037007
SMILES :
C\1CNC(=O)C2=C(/C1=C/3\C(=O)N=C(N3)N)C=C(N2)Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 110ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Meijer et al Meijer et al. (PubMed ID 10662688) found 10Z-Hymenialdisine inhibited cyclin-dependent kinases, GSK-3beta and CK1 activation by ATP. -SCBT Publication Review
Date published: 2015-02-02
  • y_2020, m_5, d_27, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_360987, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.