Molecular structure of 10Z-Hymenialdisine, CAS Number: 82005-12-7
10Z-Hymenialdisine (CAS 82005-12-7)
Alternate Names:
4Z)-4-(2-Amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
Application:
10Z-Hymenialdisine is an ATP competitive, CK1 and GSK-3β inhibitor
CAS Number:
82005-12-7
Purity:
≥97%
Molecular Weight:
324.13
Molecular Formula:
C11H10BrN5O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
10Z-Hymenialdisine is predominantly used in biochemical research as an inhibitor of various protein kinases, which are key enzymes in the regulation of cellular processes. Its role in inhibiting cyclin-dependent kinases and glycogen synthase kinase-3 beta makes it useful for studying cell cycle regulation and neuronal signaling pathways. Researchers employ 10Z-Hymenialdisine to explore the mechanisms by which these kinases affect cellular behavior, including growth, division, and differentiation. This compound is also instrumental in studies aimed at understanding the molecular basis of diseases that involve dysregulation of kinase activity. By inhibiting specific kinases, 10Z-Hymenialdisine helps elucidate their functions and interactions within the cell, providing insights that are for advancing the field of molecular biology.
10Z-Hymenialdisine (CAS 82005-12-7) References
- Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. | Meijer, L., et al. 2000. Chem Biol. 7: 51-63. PMID: 10662688
- Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). | Tasdemir, D., et al. 2002. J Med Chem. 45: 529-32. PMID: 11784156
- Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase. | Mallon, R., et al. 2004. Mol Cancer Ther. 3: 755-62. PMID: 15210862
- Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. | Bullock, AN., et al. 2009. Structure. 17: 352-62. PMID: 19278650
- A journey under the sea: the quest for marine anti-cancer alkaloids. | Tohme, R., et al. 2011. Molecules. 16: 9665-96. PMID: 22113577
- Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay. | Wang, D., et al. 2012. Bioorg Med Chem Lett. 22: 168-71. PMID: 22154664
- Kinase inhibitor scaffolds against neurodegenerative diseases from a Southern Australian ascidian, Didemnum sp. | Plisson, F., et al. 2012. ChemMedChem. 7: 983-90. PMID: 22532438
- Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. | Kettle, JG., et al. 2015. J Med Chem. 58: 2834-44. PMID: 25738750
- Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase. | Torrie, LS., et al. 2019. PLoS One. 14: e0217828. PMID: 31150492
- Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. | Benchekroun, M., et al. 2020. Eur J Med Chem. 201: 112337. PMID: 32659605
- ERRα promotes pancreatic cancer progression by enhancing the transcription of PAI1 and activating the MEK/ERK pathway. | Liu, SL., et al. 2020. Am J Cancer Res. 10: 3622-3643. PMID: 33294258
- 10Z‑Hymenialdisine inhibits angiogenesis by suppressing NF‑κB activation in pancreatic cancer cell lines. | Ueda, G., et al. 2022. Oncol Rep. 47: PMID: 35014682
- Bioactive alkaloids from the tropical marine sponge Axinella carteri. | Supriyono, A., et al. 1995. Z Naturforsch C J Biosci. 50: 669-74. PMID: 8579685
- The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB. | Breton, JJ. and Chabot-Fletcher, MC. 1997. J Pharmacol Exp Ther. 282: 459-66. PMID: 9223588
- Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. | Roshak, A., et al. 1997. J Pharmacol Exp Ther. 283: 955-61. PMID: 9353419
Inhibitor of:
Cdk1, Cdk2, Cdk3, Cdk5, cyclin A, cyclin B, cyclin E, Enzyme, MARK, MEK-1, and p35.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10Z-Hymenialdisine, 500 µg | sc-360987 | 500 µg | $210.00 |