Date published: 2026-2-14

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CDK2AP1 Inhibitors

CDK2AP1 inhibitors belong to a specific category of small organic molecules that are designed to selectively modulate the activity of the Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1). CDK2AP1, a regulatory protein, plays a pivotal role in cell cycle progression and cell division by interacting with cyclin-dependent kinases (CDKs) and their associated cyclins. The inhibitors are designed to interact with the active site or allosteric sites of CDK2AP1, effectively impeding its normal function. By binding to the protein, these inhibitors disrupt the intricate molecular interactions that govern cell cycle regulation. The structural diversity of CDK2AP1 inhibitors allows for a range of interactions, including hydrogen bonding, hydrophobic interactions, and electrostatic forces, ultimately leading to inhibition of the target protein's enzymatic activity. The development of CDK2AP1 inhibitors represents an ongoing area of research in the field of chemical biology, contributing to a deeper understanding of cellular processes and opening avenues for the development of novel approaches in disease intervention.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

R547

741713-40-6sc-364596
sc-364596A
2 mg
5 mg
$375.00
$395.00
(0)

R547 is a small molecule inhibitor of CDK2AP1 that has shown potential in research studies as an anti-cancer agent. It was developed by Rigel Pharmaceuticals and was being investigated for its ability to disrupt cell cycle progression.

UCN-01

112953-11-4sc-202376
500 µg
$251.00
10
(1)

UCN-01 is a natural product-derived compound that inhibits multiple CDKs, including CDK2APWhile its primary mechanism of action is the inhibition of protein kinases, it also affects CDK2AP1-mediated functions.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$94.00
$265.00
42
(2)

Roscovitine is a CDK inhibitor that targets various CDKs, including CDK2APIt has been studied for its potential anti-cancer effects by inducing cell cycle arrest and apoptosis.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$61.00
$153.00
$231.00
$505.00
1
(1)

Kenpaullone is a small molecule inhibitor that targets several kinases, including CDK2APIt has been explored in research as a potential anti-cancer agent due to its impact on cell cycle regulation.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$259.00
41
(3)

Flavopiridol is a synthetic flavonoid compound that inhibits multiple CDKs, including CDK2APIt has been investigated for its potential to block cell cycle progression and induce apoptosis in cancer cells.

PHA 767491 hydrochloride

942425-68-5sc-204187
sc-204187A
10 mg
50 mg
$198.00
$802.00
3
(2)

PHA-767491 is a selective CDK inhibitor that affects CDK2AP1 as well as other CDKs. It has been studied for its potential to inhibit tumor growth by disrupting cell cycle control.

AT7519

844442-38-2sc-364416
sc-364416A
sc-364416B
sc-364416C
5 mg
10 mg
100 mg
1 g
$291.00
$341.00
$1046.00
$3126.00
1
(0)

AT7519 is a multi-CDK inhibitor that includes CDK2AP1 among its targets. It has been evaluated in research and early clinical studies for its anti-cancer properties.

Dinaciclib

779353-01-4sc-364483
sc-364483A
5 mg
25 mg
$247.00
$888.00
1
(0)

Dinaciclib is a potent CDK inhibitor that affects CDK2AP1 and other CDKs. It has been investigated for its potential to suppress cancer cell growth and enhance apoptosis.

Palbociclib

571190-30-2sc-507366
50 mg
$321.00
(0)

While primarily known for its inhibition of CDK4/6, PD-0332991 also affects CDK2AP1 to some extent.

Abemaciclib

1231929-97-7sc-507342
10 mg
$110.00
(0)

Similar to PD-0332991, LY2835219 is a CDK4/6 inhibitor with some activity against CDK2AP