Date published: 2025-11-21

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Cdk2 Inhibitors

Cyclin-dependent kinase 2 (Cdk2) inhibitors represent a class of chemical compounds that play a pivotal role in regulating the progression of the cell cycle. Cdk2, a member of the cyclin-dependent kinase family, is a serine/threonine kinase enzyme that partners with various cyclins to control the transition between different phases of the cell cycle. The inhibitors targeting Cdk2 are designed to modulate its activity, primarily by preventing the interaction between Cdk2 and its binding partner, cyclin. By doing so, these inhibitors disrupt the phosphorylation events that are critical for cell cycle progression. Cdk2 inhibitors exhibit a diverse range of chemical structures, each tailored to specifically interact with the active site of the enzyme. These compounds often contain conserved motifs that are crucial for binding to the ATP-binding pocket of Cdk2. By binding to this pocket, the inhibitors compete with ATP molecules, thereby obstructing the enzymatic activity of Cdk2. This binding interaction leads to a halt in the phosphorylation of key substrates involved in cell cycle progression, ultimately resulting in cell cycle arrest. The rational design of Cdk2 inhibitors involves a detailed understanding of the enzyme's structural features and catalytic mechanisms, allowing chemists to fine-tune the compounds for optimal binding affinity and specificity.

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Items 11 to 20 of 53 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1-Naphthyl PP1

221243-82-9sc-203765
sc-203765A
10 mg
50 mg
$230.00
$964.00
3
(1)

1-Naphthyl PP1 (CAS 221243-82-9) is a chemical compound recognized as a potent inhibitor of Cdk2, a key enzyme involved in cell cycle regulation. This compound effectively modulates Cdk2 activity, impacting cellular processes related to cell division and growth control.

Purvalanol B

212844-54-7sc-361300
sc-361300A
10 mg
50 mg
$199.00
$846.00
(1)

Purvalanol B (CAS 212844-54-7) is a chemical compound known for its role as a Cdk2 inhibitor. It affects the activity of Cdk2, a protein involved in cell cycle regulation. The compound's interaction with Cdk2 influences cellular processes, offering insights into cell cycle dynamics.

10Z-Hymenialdisine

82005-12-7sc-360987
500 µg
$210.00
(1)

10Z-Hymenialdisine (CAS 82005-12-7) is a chemical compound known for its role as a Cdk2 inhibitor. It exhibits inhibitory effects on Cdk2, a crucial protein involved in cell cycle regulation. This compound's interaction with Cdk2 highlights its potential significance in influencing cellular processes.

P276-00

920113-03-7sc-477932
1 mg
$380.00
(0)

P276-00 inhibits CDK2 by binding to the ATP-binding site, disrupting cell cycle progression and triggering apoptosis in cancer cells.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$112.00
$515.00
4
(1)

Indirubin (CAS 479-41-4) acts as a Cdk2 inhibitor, impacting cell cycle regulation. It modulates critical cellular processes without clinical application or drug use references.

Aminopurvalanol A

220792-57-4sc-223775
sc-223775A
1 mg
5 mg
$51.00
$118.00
(1)

Aminopurvalanol A (CAS 220792-57-4) is a chemical compound acting as a potent inhibitor of Cdk2, a crucial protein involved in cell cycle regulation. It modulates Cdk2 activity, impacting cell processes.

Cdk4 Inhibitor Inhibitor

546102-60-7sc-203873
1 mg
$134.00
5
(1)

The chemical compound with CAS 546102-60-7 is a Cdk4 inhibitor that also affects Cdk2. It modulates cell cycle progression by targeting these kinases.

A-674563

552325-73-2sc-364393
sc-364393A
2 mg
5 mg
$232.00
$413.00
(1)

A-674563 (CAS 552325-73-2) is a chemical compound known for its role as a Cdk2 inhibitor. It modulates Cdk2 activity, impacting cellular processes.

SNS-032

345627-80-7sc-364621
sc-364621A
5 mg
10 mg
$169.00
$262.00
(1)

SNS-032 is a selective CDK2 inhibitor that competes with ATP binding, leading to cell cycle arrest and inhibiting transcription by CDK9.

NU6102

444722-95-6sc-222082
sc-222082A
1 mg
5 mg
$55.00
$122.00
3
(1)

NU6102 inhibits CDK2 by competing for the ATP-binding site, arresting cell cycle progression and promoting tumor cell death.