CdcA7L Activators
CdcA7L activators encompass a diverse array of chemical compounds that influence specific cellular pathways, leading to the enhanced functional activity of CdcA7L. Forskolin, for example, increases intracellular cAMP, which subsequently activates PKA, a kinase that can phosphorylate and thereby activate target proteins including CdcA7L. This mechanism underscores the direct influence certain small molecules can exert on the activity of specific proteins through well-defined biochemical pathways. Similarly, compounds like Resveratrol and Spermidine act through the activation of SIRT1 and the induction of autophagy respectively, both of which can indirectly foster a cellular milieu conducive to the activation of CdcA7L by modifying the activity or expression of regulatory proteins.
Furthermore, agents such as Epigallocatechin gallate and Curcumin modulate epigenetic mechanisms or transcription factors like NF-κB to enhance the expression of certain genes, which may include those coding for CdcA7L or its activators. Sodium butyrate and 5-Azacytidine, by inhibiting histone deacetylases and DNA methyltransferases respectively, canalter chromatin structure and DNA methylation patterns, potentially leading to increased transcription and subsequent activation of CdcA7L. Lithium chloride's inhibition of GSK-3 may prevent the phosphorylation-based inactivation of proteins, allowing for the stabilization and activation of CdcA7L, illustrating another facet of how small molecules can influence protein activity. Retinoic acid and Sulforaphane, by engaging with transcriptional pathways, can also upregulate genes and create an antioxidative environment that supports CdcA7L activity. Lastly, Piperine and Quercetin can modulate enzyme activity and kinase activity, respectively, leading to changes in the levels of regulatory molecules and affecting phosphorylation patterns, which may result in enhanced activation of CdcA7L.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can enhance the phosphorylation of specific proteins, including CdcA7L, potentially leading to its activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits the activity of DNA methyltransferases, which may decrease methylation on the promoter regions of certain genes, potentially enhancing the expression and activity of proteins such as CdcA7L. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the activity of NF-κB, a transcription factor that regulates the expression of a variety of genes, including those that could upregulate the production and activity of CdcA7L. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a protein deacetylase, which can deacetylate and activate members of the Forkhead box (FoxO) family of transcription factors. These factors may enhance the transcription of genes like those coding for CdcA7L. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy, a cellular process that can affect numerous signaling pathways and may lead to the enhanced activation of proteins through the clearance of regulatory inhibitors, potentially affecting CdcA7L activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is a histone deacetylase inhibitor, which leads to a more relaxed chromatin structure and potentially increased transcription of genes, including those that encode activators of CdcA7L. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA, inhibiting DNA methyltransferases, which could lead to the hypomethylation and potentially increased expression of genes involved in the activation of CdcA7L. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which may prevent the phosphorylation and inactivation of target proteins, potentially leading to the stabilization and activation of CdcA7L. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs), which act as transcription factors that regulate gene expression, possibly upregulating genes that enhance the activity of CdcA7L. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, leading to the expression of antioxidant response element (ARE)-driven genes. This activation may indirectly enhance the cellular environment in which CdcA7L operates. | ||||||