Cdc27 Inhibitors
Cdc27 inhibitors represent a class of chemical compounds designed to target and disrupt the activity of the Cdc27 protein within the cell cycle regulatory machinery. Cdc27, also known as ANAPC3 (Anaphase Promoting Complex Subunit 3), is a crucial component of the Anaphase-Promoting Complex/Cyclosome (APC/C), which plays a pivotal role in regulating the progression of the eukaryotic cell cycle. The cell cycle is a highly orchestrated process that ensures the accurate duplication and segregation of genetic material during cell division.
To maintain this precision, the APC/C, with Cdc27 as one of its core subunits, regulates the degradation of specific proteins at key checkpoints, allowing the cell cycle to progress in a controlled manner. Cdc27 inhibitors are designed to interfere with the function of Cdc27, disrupting the proper functioning of the APC/C and, consequently, the cell cycle progression. By inhibiting Cdc27, these compounds can perturb the normal degradation of cell cycle regulators, leading to cell cycle arrest or dysregulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of Cdc27 by the proteasome. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis, indirectly affecting the expression of Cdc27. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide can modulate the expression of various proteins, including those in cell cycle regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 disrupts the interaction between Mdm2 and p53, which indirectly affects cell cycle regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, impacting downstream targets involved in cell cycle control. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin can induce DNA damage responses that may affect cell cycle regulatory proteins like Cdc27. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil interferes with DNA synthesis and may indirectly affect Cdc27 expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin can induce DNA damage and activate p53, potentially impacting Cdc27 regulation. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 inhibits mTOR kinase activity, which can affect the downstream targets related to cell cycle control. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and may interfere with mitosis and APC/C activity, affecting Cdc27. | ||||||