Cdc27 Activators
Cdc27 activators represent a fascinating class of molecules within the realm of cellular biology and molecular regulation. To understand their significance, it's essential to delve into the intricacies of the cell cycle and the vital role of the anaphase-promoting complex/cyclosome (APC/C). Cdc27, also known as APC3, is one of the key components of the APC/C, a multi-subunit E3 ubiquitin ligase complex that orchestrates the progression of eukaryotic cells through the cell cycle. This complex plays a pivotal role in ensuring the accurate segregation of chromosomes during cell division, thereby preserving genomic integrity.
Cdc27 activators are molecules or factors that modulate the activity of Cdc27, thereby influencing the APC/C's ability to target specific proteins for ubiquitination and subsequent degradation. These activators are pivotal in finely tuning the cell cycle by regulating the timing and progression of various cell cycle phases, including G1, S, G2, and M. They function by enhancing the association of Cdc27 with the APC/C complex, thereby promoting the ubiquitination and degradation of specific cell cycle regulators or substrates. This tight control over the cell cycle progression is essential for the maintenance of cellular homeostasis and prevention of aberrant cell division, which can lead to various pathological conditions, including cancer. Understanding the mechanisms and regulation of Cdc27 activators is thus crucial for unraveling the intricate network of cellular processes governing cell proliferation and genomic stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in grapes, which may enhance Cdc27 expression as part of its broader impact on cell cycle regulation and cellular stress response mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Found in turmeric, curcumin is known for its anti-inflammatory properties. It may modulate Cdc27 expression as part of its effects on cell proliferation and apoptosis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid present in many fruits and vegetables, quercetin may influence Cdc27 expression as it has been shown to affect cell cycle progression and apoptosis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Derived from cruciferous vegetables, sulforaphane may alter Cdc27 levels as it influences cell cycle arrest and apoptosis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A soy isoflavone, genistein has been shown to modulate cell cycle regulators and may impact Cdc27 expression in connection with its roles in cell proliferation and differentiation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
The major catechin in green tea, EGCG can potentially influence Cdc27 expression as part of its regulatory effects on the cell cycle. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate can disrupt cell cycle progression and may influence Cdc27 expression as it interferes with DNA synthesis and repair. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits DNA synthesis and may impact Cdc27 expression as part of its cell cycle-arresting effects. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A, retinoic acid plays a key role in cell differentiation and may alter Cdc27 expression as part of its effects on cell cycle regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytosine analog used in epigenetic studies, 5-aza-2'-deoxycytidine may influence Cdc27 expression as it induces DNA demethylation, potentially affecting gene expression. | ||||||