Cdc13 Activators
Cdc13 is a pivotal protein in the maintenance of telomeres, the protective caps on the ends of eukaryotic chromosomes, in the model organism Saccharomyces cerevisiae. It performs a critical role by binding to the single-stranded overhang of telomeric DNA, thereby preventing the chromosome ends from being erroneously repaired as double-strand breaks, which would be catastrophic for genome integrity. Furthermore, Cdc13 is instrumental in the regulation of telomerase, an enzyme complex responsible for adding DNA sequence repeats to compensate for the loss of terminal DNA sequences that occurs with each round of DNA replication. Through these functions, Cdc13 is essential for preserving chromosomal stability and supporting the replicative lifespan of the cell.
Given its central role in telomere maintenance, the expression of Cdc13 can be influenced by various chemical compounds that are known to create cellular environments necessitating enhanced telomere protection and repair. These activators often induce stress responses that are associated with DNA damage, replication challenges, or oxidative stress, conditions that are known to affect telomere length and integrity. For instance, agents that cause direct DNA damage or replication stress can lead to an upsurge in Cdc13 expression as the cell mobilizes its repair mechanisms. Similarly, oxidative agents can induce a state that mimics telomeric DNA damage, again potentially leading to increased Cdc13 levels. Understanding these activators and the conditions they create is critical for elucidating the complex network of cellular pathways that govern telomere maintenance and the role of Cdc13 within this network. These insights contribute significantly to our fundamental comprehension of chromosome biology in eukaryotic organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Methyl methanesulfonate introduces alkyl groups to the DNA bases, leading to errors in replication and repair that may necessitate the upregulation of Cdc13 for telomere integrity safeguarding. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
By depleting deoxyribonucleotide pools, Hydroxyurea causes replication forks to stall, potentially increasing the expression of Cdc13 to manage telomere maintenance under replicative stress conditions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin traps topoisomerase I-DNA cleavable complexes, inducing single-strand DNA breaks that may drive the upsurge in Cdc13 expression to assist in telomere capping and genome stabilization. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine's inhibition of DNA damage repair kinases can lead to persistent DNA damage signals, possibly necessitating the elevation of Cdc13 expression to overcome telomere uncapping and preserve chromosomal ends. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
By producing DNA strand breaks, Bleomycin may trigger a cellular response that includes the induction of Cdc13, aiming to enhance the protective cap at chromosome ends. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine intercalates into DNA and disrupts its replication and repair, potentially leading to an induction of Cdc13 expression to counteract damage at the telomeres and ensure chromosomal stability. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound's incorporation into nucleic acids can mimic cytosine methylation patterns, possibly prompting an increase in Cdc13 expression as an adaptive response to perceived methylation stress at the chromosome ends. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
By stabilizing topoisomerase II-DNA complexes, Etoposide causes DNA double-strand breaks, which can enhance Cdc13 expression as part of the cellular strategy to repair and protect telomeric DNA. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to the DNA template and impedes RNA polymerase movement, which can lead to replication stress, potentially stimulating the expression of Cdc13 for telomere maintenance and cell cycle progression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin's intercalation into DNA and topoisomerase II inhibition result in DNA damage, which may necessitate an increase in Cdc13 expression to mitigate risks to telomere structure and function during the DNA damage response. | ||||||