Date published: 2025-10-15

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CD81 Activators

CD81 Activators pertains to a class of chemicals or compounds that modulate the activity of CD81, a transmembrane protein belonging to the tetraspanin family. CD81 plays a substantial role in various cellular processes including cell-cell interactions and cellular trafficking. Particularly, it's known to be a crucial part of tetraspanin-enriched microdomains (TERMs), which serve as platforms for receptor clustering and signaling. Furthermore, CD81 facilitates the trafficking and compartmentalization of the CD19 receptor on the surface of activated B cells and acts as a scaffold for signaling molecules, aiding in the initiation of signaling cascades . The modulation of CD81 can influence immune cell interactions and activation. For instance, Anti-CD81 has been shown to activate LFA-1 on T cells and promote T cell-B cell adhesion, affecting subsequent immune responses such as T cell activation, IL-2 production, and proliferation. Specifically, a study noted that the antibody 5A6 was uniquely potent in mediating these effects compared to other antibodies targeting CD81 or other tetraspanins expressed on T cells. The engagement of CD81 led to the rapid induction of high-avidity LFA-1, which is instrumental in cell adhesion and immune interactions .

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Farnesyl thiosalicylic acid

162520-00-5sc-205322
sc-205322A
1 mg
5 mg
$60.00
$80.00
15
(1)

This compound is primarily known as a Ras inhibitor. However, it has been shown to increase the level of CD81 in some cellular contexts, potentially aiding in immune cell activation.

Glyburide (Glibenclamide)

10238-21-8sc-200982
sc-200982A
sc-200982D
sc-200982B
sc-200982C
1 g
5 g
25 g
100 g
500 g
$45.00
$60.00
$115.00
$170.00
$520.00
36
(1)

This chemical can modulate the functions of various proteins and receptors. Although primarily aimed at reducing blood sugar in research studies, it has been implicated in CD81 activation through cellular signaling pathways.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Predominantly a kinase inhibitor, Sorafenib has shown potential for CD81 activation by modulating receptor clustering and downstream signaling.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

This flavonoid can interact with various cellular components. It has been studied for its ability to modulate CD81 activity through its antioxidant and anti-inflammatory properties.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Found in turmeric, curcumin can modulate CD81 activity through its anti-inflammatory and immunomodulatory effects, potentially enhancing immune cell adhesion.

Amlodipine

88150-42-9sc-200195
sc-200195A
100 mg
1 g
$73.00
$163.00
2
(1)

This calcium channel blocker has been suggested to activate CD81 through calcium-dependent signaling pathways.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$60.00
$108.00
21
(1)

Used as an antipsychotic drug, chlorpromazine has been implicated in CD81 activation potentially through the modulation of lipid rafts where CD81 resides.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

This compound is known for its antioxidant properties. It has been shown to activate CD81 through modulation of cellular redox status.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$62.00
$90.00
$299.00
$475.00
$1015.00
$2099.00
69
(5)

This immunosuppressant can paradoxically activate CD81 under specific conditions, likely by altering cellular signaling cascades.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Primarily an immunosuppressant, Rapamycin may activate CD81 through its effects on cellular protein synthesis and signaling pathways.