Date published: 2026-2-14

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CD206 Inhibitors

CD206 inhibitors encompass a range of compounds designed to target and inhibit the activity of the CD206 receptor, also known as the mannose receptor. CD206 is a type I transmembrane protein predominantly expressed on the surface of macrophages and dendritic cells. It is characterized by multiple C-type lectin domains that enable it to bind to carbohydrate structures, including mannose, fucose, and N-acetylglucosamine, which are commonly found on the surface of pathogens and endogenous glycoproteins. The receptor plays a role in endocytosis, mediating the internalization and clearance of glycosylated molecules. CD206 inhibitors aim to block the binding of ligands to the receptor, thus inhibiting the receptor's ability to internalize these molecules. The design of these inhibitors involves creating molecules that can either competitively or non-competitively interact with the carbohydrate recognition domains of CD206, preventing the normal ligand-receptor interactions. The chemical development of CD206 inhibitors requires a thorough understanding of the receptor's structure and the ligand-binding process. Inhibitors may be specifically tailored to mimic the natural ligands' structure, thus competing for the binding sites on the receptor, or they may be designed to bind to allosteric sites, altering the receptor's conformation and preventing ligand recognition. A

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Amiloride • HCl

2016-88-8sc-3578
sc-3578A
25 mg
100 mg
$22.00
$57.00
6
(2)

Amiloride, a potassium-sparing diuretic, has been shown to inhibit the function of CD206 by interfering with its endocytosis process. Through this mechanism, it may also down-regulate the protein's expression or activity.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein, an isoflavonoid found in soy products, can inhibit various cellular processes. It's speculated that genistein might suppress CD206 expression, potentially through its broader anti-inflammatory effects.

Polysorbate 60

9005-67-8sc-281134
sc-281134A
100 ml
500 ml
$38.00
$60.00
(0)

Mannan can competitively bind to CD206, preventing its interaction with its natural ligands. This competitive inhibition might lead to reduced CD206 expression as cells often decrease production of receptors that are persistently occupied.

Piceatannol

10083-24-6sc-200610
sc-200610A
sc-200610B
1 mg
5 mg
25 mg
$51.00
$71.00
$199.00
11
(2)

Piceatannol, a metabolite of resveratrol, has been found to inhibit several signaling pathways. It may indirectly affect CD206 expression through its modulatory effects on macrophage activation.

Nystatin

1400-61-9sc-212431
sc-212431A
sc-212431B
sc-212431C
5 MU
25 MU
250 MU
5000 MU
$51.00
$129.00
$251.00
$3570.00
7
(1)

Nystatin, an antifungal agent, can interfere with cellular cholesterol, which might disrupt lipid rafts and the localization or function of several receptors, potentially including CD206.

W-7

61714-27-0sc-201501
sc-201501A
sc-201501B
50 mg
100 mg
1 g
$166.00
$306.00
$1675.00
18
(1)

W-7 is a calmodulin antagonist. By inhibiting calmodulin, it can affect several cellular processes, which might indirectly reduce the expression or activity of CD206.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$61.00
$110.00
21
(1)

Chlorpromazine is an antipsychotic that affects various cellular processes. It can potentially inhibit CD206 expression or function, possibly through its effects on cell membranes and associated proteins.

Methyl-β-cyclodextrin

128446-36-6sc-215379A
sc-215379
sc-215379C
sc-215379B
100 mg
1 g
10 g
5 g
$20.00
$48.00
$160.00
$82.00
19
(1)

This compound depletes cholesterol from cell membranes, potentially disrupting the function of lipid rafts. This can impact the localization or function of several membrane proteins, including possibly CD206.

Filipin III

480-49-9sc-205323
sc-205323A
500 µg
1 mg
$118.00
$148.00
26
(2)

Filipin binds to cholesterol in cell membranes, potentially disrupting lipid rafts. This can affect the function or expression of several receptors, and might have implications for CD206.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$89.00
44
(2)

Dynasore is a non-competitive inhibitor of the GTPase activity of dynamin, which is involved in endocytosis. By inhibiting endocytosis, dynasore can impact the function or expression of endocytic receptors, potentially including CD206.