CD203a Inhibitors
CD203a inhibitors are chemical compounds that target the enzyme CD203a, also known as ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3). CD203a is a membrane-bound enzyme that belongs to the ENPP family, which plays a crucial role in the hydrolysis of extracellular nucleotides, converting them into pyrophosphate and nucleotide monophosphates. This enzymatic activity is significant in various biological processes, such as modulating purinergic signaling pathways and maintaining nucleotide balance in the extracellular space. By inhibiting CD203a, these compounds aim to block the enzyme's ability to catalyze these reactions, thereby affecting processes related to nucleotide metabolism and signaling in tissues where CD203a is expressed, including the gastrointestinal tract, kidneys, and immune system cells.
CD203a inhibitors are designed with structural features that allow them to specifically bind to the active site of the enzyme, blocking its catalytic activity. These inhibitors can range from small molecules to larger biologic entities, and their design requires a detailed understanding of the enzyme's three-dimensional structure and the dynamics of its active site. The inhibitors must also be optimized for selectivity, ensuring they effectively target CD203a without interfering with other members of the ENPP family, which may have overlapping functions. Additionally, factors such as binding affinity, solubility, and stability of the inhibitors are important considerations during their development. By inhibiting CD203a, these compounds serve as valuable tools for exploring the enzyme's role in cellular signaling, extracellular nucleotide regulation, and its broader biological functions across different tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin may downregulate CD203a expression by competitively inhibiting binding sites of growth factors involved in the signaling cascades that would ordinarily enhance the transcription of CD203a. | ||||||
Clopidogrel | 113665-84-2 | sc-507403 | 1 g | $120.00 | 1 | |
Clopidogrel may reduce CD203a expression by inhibiting adenosine diphosphate (ADP) receptors on cell surfaces, thereby attenuating the ADP-mediated signal transduction pathways that promote CD203a transcription. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
Alendronate could inhibit CD203a expression by disrupting the mevalonate pathway, which is crucial for post-translational modifications necessary for the function of proteins that drive CD203a expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone may decrease CD203a expression by activating peroxisome proliferator-activated receptor gamma (PPARγ), which can lead to the repression of genes involved in inflammation that may include CD203a. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib could decrease CD203a expression by specifically inhibiting tyrosine kinases that are upstream regulators of transcriptional processes governing the expression of CD203a. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could downregulate CD203a expression by suppressing the activation of transcription factors such as NF-κB, which are known to drive the expression of inflammatory genes including CD203a. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might inhibit CD203a expression by activating sirtuin 1 (SIRT1), leading to deacetylation of transcription factors and subsequent repression of pro-inflammatory genes expressing CD203a. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin could decrease CD203a expression by irreversibly inhibiting cyclooxygenase enzymes, which would reduce the synthesis of prostaglandins and thromboxanes, thereby lowering the inflammatory response that could otherwise upregulate CD203a. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
Eicosapentaenoic acid may reduce CD203a expression by competing with arachidonic acid for the cyclooxygenase and lipoxygenase pathways, leading to the production of anti-inflammatory mediators that can suppress the expression of pro-inflammatory proteins including CD203a. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could inhibit CD203a expression by interfering with the metabolism of folic acid, which is necessary for the synthesis of purines and the subsequent proliferation of cells that express CD203a, leading to a decrease in its overall expression. | ||||||