CD200R4 Activators
Cd200r4, a pivotal gene encoding CD200 receptor 4, is fundamentally involved in enabling signaling receptor activity, particularly in the regulation of neuroinflammatory responses within diverse tissues such as the ductus deferens, epididymis, ileum, and tongue. Positioned on the external side of the plasma membrane, Cd200r4 is intricately associated with the orchestration of neuroinflammatory processes. The gene's orthologs in humans, CD200R1 and CD200R1L, further underline its evolutionary significance, pointing towards conserved functions in immune regulation. The known and predicted function of Cd200r4 is primarily centered around its role as a modulator of neuroinflammatory responses. This implies that Cd200r4 functions as a critical regulatory element, potentially fine-tuning the delicate balance of immune responses within specific tissues.
Activation of Cd200r4 involves intricate cellular mechanisms that are finely tuned to modulate neuroinflammatory responses. While the specific chemical modulators have distinct modes of action, they collectively converge on enhancing the expression and signaling activity of Cd200r4. These modulators act through various pathways, such as cAMP-dependent signaling, PKC activation, and modulation of transcriptional factors like NF-κB and SIRT1. Additionally, some compounds exert their effects through calcium-mediated pathways and histone acetylation, underscoring the complexity of the regulatory networks governing Cd200r4 activation. Understanding these diverse mechanisms provides insights into the multifaceted nature of Cd200r4's involvement in immune regulation and highlights its potential significance in influencing broader cellular processes beyond the scope of neuroinflammation. The intricate interplay of these modulators on Cd200r4 expression showcases the gene's adaptability to various regulatory inputs, positioning it as a central player in the dynamic landscape of cellular responses and immune regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates Cd200r4 by elevating cAMP levels, stimulating PKA, which then enhances the expression of Cd200r4. This chemical promotes neuroinflammatory response regulation through cAMP-mediated signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Indirect activator of Cd200r4 via SIRT1 activation. Modulates the NAD-dependent deacetylase, leading to increased Cd200r4 expression. This compound influences neuroinflammatory response regulation through the SIRT1 pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates Cd200r4 by activating PKC, which phosphorylates and enhances the transcriptional activity of Cd200r4. This compound directly promotes neuroinflammatory response regulation through the PKC pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Upregulates Cd200r4 via inhibition of NF-κB. Blocks NF-κB signaling, resulting in increased Cd200r4 expression. This compound indirectly promotes neuroinflammatory response regulation through NF-κB modulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Activates Cd200r4 by binding to its promoter region and promoting gene expression. This compound directly enhances neuroinflammatory response regulation through the retinoic acid signaling pathway. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Indirect activator of Cd200r4 via cAMP elevation. Enhances Cd200r4 expression by stimulating PKA through a cAMP-dependent mechanism. This chemical influences neuroinflammatory response regulation through cAMP-mediated signaling. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Upregulates Cd200r4 by inhibiting HDACs. Indirectly enhances Cd200r4 gene expression through histone acetylation modulation. This compound promotes neuroinflammatory response regulation through epigenetic modification. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Activates Cd200r4 by increasing intracellular calcium levels. Elevates calcium signaling, leading to enhanced Cd200r4 expression. This chemical directly promotes neuroinflammatory response regulation through calcium-mediated pathways. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Indirect activator of Cd200r4 through TGF-β pathway modulation. Blocks TGF-β receptor activation, resulting in increased Cd200r4 expression. This compound influences neuroinflammatory response regulation through TGF-β signaling pathway interference. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Upregulates Cd200r4 by inhibiting caspases. Prevents caspase-mediated Cd200r4 degradation, leading to increased expression. This compound indirectly promotes neuroinflammatory response regulation through caspase inhibition. | ||||||