CCT8L1 Activators
CCT8L1 Activators encompass a diverse array of chemical compounds that each uniquely contribute to the enhancement of CCT8L1 functional activity through distinct yet complementary signaling pathways. Forskolin and IBMX exert their effects by augmenting intracellular cAMP levels, thereby activating PKA, a kinase capable of phosphorylating proteins within the CCT8L1 complex, thus enhancing CCT8L1's role in protein folding and stabilization. Similarly, PMA activates PKC, which influences CCT8L1 functionality through post-translational modifications. Additionally, the calcium ionophores Ionomycin and A23187 increase intracellular calcium levels, resulting in the activation of calcium-dependent kinases that are likely to impact CCT8L1 activity by altering itsconformation or that of CCT8L1-associated proteins. These biochemical alterations can enhance the chaperonin's ability to interact with and stabilize its target proteins, which is vital for maintaining cellular homeostasis.
The polyphenol EGCG may attenuate the activity of various kinases, thereby influencing CCT8L1 through the modulation of phosphorylation states of CCT8L1-interacting proteins. The presence of the polyamine spermine contributes to the enhancement of CCT8L1 by stabilizing nucleic acid-protein complexes, potentially increasing CCT8L1's ability to effectively interact with its substrates. Oleic Acid, by affecting membrane fluidity, may indirectly influence membrane-associated signaling pathways and enhance CCT8L1's interactions within the cell membrane context. Furthermore, Sildenafil and Tadalafil, by inhibiting PDE5 and elevating cyclic nucleotide levels, activate PKA and PKG, kinases that can phosphorylate and thereby enhance the activity of CCT8L1 or its binding partners. Zinc Sulfate provides structural stability to CCT8L1, potentially facilitating its chaperone function, while Lithium Chloride's inhibition of GSK-3 may lead to an altered signaling environment conducive to CCT8L1 activation. Collectively, these CCT8L1 Activators function through a variety of mechanisms to enhance the chaperonin's vital role in ensuring proper protein folding and assembly, thereby maintaining the functional integrity of the proteome.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts by directly stimulating adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in the cell. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various targets including proteins that interact with CCT8L1, thereby enhancing its function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP degradation, IBMX indirectly results in the activation of PKA, which can modulate the activity of CCT8L1 through phosphorylation of associated proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analogue that activates protein kinase C (PKC). PKC activation leads to downstream effects on signaling pathways that can enhance the function of CCT8L1 through post-translational modifications of CCT8L1 or its interacting partners. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate calcium-dependent kinases, which in turn can enhance the activity of CCT8L1 by modifying its conformation or the activity of proteins in the CCT8L1 complex. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that elevates intracellular calcium levels, similar to Ionomycin. This elevation can activate calcium-dependent signaling pathways that indirectly enhance CCT8L1 function by promoting interactions with other chaperonin proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea that has been shown to inhibit various kinases. By modulating kinase activity, EGCG can influence the phosphorylation state of proteins that interact with CCT8L1, leading to enhanced activity of the CCT8L1 complex. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that has been shown to stabilize nucleic acid-protein complexes. This stabilization can enhance the functional interaction between CCT8L1 and its substrate proteins, indirectly increasing the activity of CCT8L1. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid is a fatty acid that integrates into cellular membranes, affecting membrane fluidity. This can influence membrane-associated signaling pathways, potentially enhancing the functional activity of CCT8L1 by altering its membrane-related interactions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc acts as a cofactor for many enzymes and can stabilize protein structures. Providing zinc can enhance the structural integrity of CCT8L1, thereby potentially improving its functional interactions with other proteins in the chaperonin complex. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to changes in signaling pathways that may enhance the activity of CCT8L1 by altering the phosphorylation state of CCT8L1 or associated proteins. | ||||||