CCT B Activators
CCT B," often referred to as "CCT2" or "TCP1 beta," is a protein encoded by the CCT2 gene in humans. It is a subunit of the chaperonin containing TCP1 complex (CCT), also known as the TCP-1 Ring Complex (TRiC). CCT/TRiC is a molecular chaperone complex essential for the proper folding of many proteins within the cell.
CCT/TRiC is composed of eight different subunits (CCT1 to CCT8), with CCT2 being one of them. Each subunit is distinct but functionally interconnected, contributing to the complex's overall ability to assist in protein folding. CCT B/CCT2 plays a crucial role in this process, helping to ensure that newly synthesized proteins attain their correct three-dimensional conformations, which is vital for their functionality.The correct folding of proteins is fundamental to cell biology as misfolded proteins can lead to various diseases, including neurodegenerative disorders like Alzheimer's disease, and Huntington's disease. CCT B/CCT2, by virtue of its role in the CCT/TRiC complex, helps in preventing such misfolding events.CCT B/CCT2 is ubiquitously expressed in various tissues, highlighting its importance across a wide range of cellular functions. It is particularly crucial in the folding of actin and tubulin, proteins that are integral to the cell's cytoskeleton and play essential roles in cell structure, division, and intracellular transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an Hsp90 inhibitor, potentially affecting chaperone-mediated protein folding and indirectly influencing CCT B activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin also targets Hsp90, influencing chaperone functions and possibly impacting CCT B indirectly. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is another Hsp90 inhibitor, which can affect protein folding pathways relevant to CCT B. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, stressing the ER and potentially influencing chaperonin functions like those of CCT B. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor, leading to increased cellular stress and potentially affecting chaperonin activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, has been shown to modulate protein aggregation and might influence CCT B activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects various signaling pathways and may modulate protein folding processes involving CCT B. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been shown to affect protein aggregation and could influence CCT B function. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
This chemical acts as a chemical chaperone, potentially affecting the folding environment relevant to CCT B. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, potentially impacting chaperonin functions like CCT B. | ||||||