CCL (C-C motif chemokine ligand) Inhibitors
C-C motif chemokine ligand (CCL) signaling plays a vital role in the immune system by mediating the migration and function of immune cells. CCLs are a family of small cytokines, part of the larger chemokine family, that bind to G protein-coupled receptors (GPCRs) on the surfaces of target cells, predominantly leukocytes. This binding triggers a cascade of intracellular signaling, leading to various cellular responses, including cell migration, or chemotaxis, toward sites of inflammation or injury. CCL signaling is crucial for the development and regulation of immune responses, assisting in the recruitment of immune cells to infection sites and promoting the organization of lymphoid tissues. Dysregulation of CCL signaling is implicated in a variety of diseases, including autoimmune disorders, infectious diseases, and cancer, due to its role in controlling the movement and activity of immune cells.
By modulating CCL signaling, these interventions aim to regulate the migration and activity of immune cells, which play a crucial role in inflammation and tumor progression. Small molecule inhibitors or antagonists that target specific CCL receptors can prevent the binding of chemokines, thereby altering immune cell recruitment and function. This approach is particularly relevant in conditions where CCLs are overexpressed or dysregulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bindarit | 130641-38-2 | sc-503560 | 5 mg | $380.00 | ||
Bindarit selectively inhibits C-C motif chemokine ligand synthesis. It hampers C-C motif chemokine ligand production by blocking the NF-kB signaling pathway, which is essential for the transcription of MCP-1 gene. | ||||||
Bis(2-carboxyethylgermanium(IV) sesquioxide) | 12758-40-6 | sc-227361 | 5 g | $76.00 | ||
Propagermanium is known to inhibit the production of MCP-1. It targets the production process at the transcriptional level, leading to decreased C-C motif chemokine ligand expression. | ||||||
BX 471 | 217645-70-0 | sc-507448 | 5 mg | $240.00 | ||
These molecules block the CCR1 receptor, affecting CCL3 (MIP-1α) mediated immune responses. | ||||||
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $55.00 $98.00 | 9 | |
Tetrandrine, a bisbenzylisoquinoline alkaloid, has shown potential to inhibit C-C motif chemokine ligand production in certain inflammatory models. It may exert its effect by suppressing related signaling pathways. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, a PPARγ agonist, has shown potential to inhibit MCP-1 production. The activation of PPARγ can lead to the transcriptional repression of inflammatory genes, including MCP-1. | ||||||
CCR2 Antagonist | 445479-97-0 | sc-202525 | 5 mg | $299.00 | 34 | |
A CCR2 antagonist that inhibits CCL2 signaling, potentially useful in characterized by chronic inflammation. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen is an antioxidant that can inhibit C-C motif chemokine ligand production. By reducing oxidative stress, which is a known inducer of C-C motif chemokine ligand, ebselen can lead to decreased C-C motif chemokine ligand levels. | ||||||
Zafirlukast | 107753-78-6 | sc-204942 sc-204942A | 10 mg 100 mg | $36.00 $171.00 | 1 | |
Another leukotriene receptor antagonist, Zafirlukast can inhibit the action of leukotrienes, thereby affecting C-C motif chemokine ligand family activity. | ||||||
ONO 1078 | 103177-37-3 | sc-204148 | 50 mg | $65.00 | ||
Pranlukast blocks leukotriene receptors and can therefore limit the activation of C-C motif chemokine ligand family indirectly. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton inhibits 5-lipoxygenase, which reduces leukotriene production, affecting the pathways that stimulate C-C motif chemokine ligand family. | ||||||