Molecular structure of ONO 1078, CAS Number: 103177-37-3
ONO 1078 (CAS 103177-37-3)
Alternate Names:
Pranlukast
Application:
ONO 1078 is a CysLT1 antagonist that downplays contraction of smooth airway muscle
CAS Number:
103177-37-3
Molecular Weight:
481.5
Molecular Formula:
C27H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ONO 1078 is a chemical compound that plays a role in the regulation of certain biochemical processes. It is involved in the modulation of specific enzymes and receptors, impacting various metabolic pathways. ONO 1078 can interact with key proteins, influencing their activity and ultimately affecting cellular function. ONO 1078 has been the subject of biochemistry that aims to further understand its mechanisms of action. ONO 1078 is a significant molecule in cellular signaling and has implications for various physiological functions. Its role in the regulation of biochemical pathways makes it an important area of study in the field of biochemistry.
ONO 1078 (CAS 103177-37-3) References
- Effects of ONO-1078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma. | Tohda, Y., et al. 1999. Clin Exp Allergy. 29: 1532-6. PMID: 10520082
- Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats. | Zhang, WP., et al. 2002. Acta Pharmacol Sin. 23: 871-7. PMID: 12370090
- In vivo pharmacologic profile of ONO-1078: a potent, selective and orally active peptide leukotriene (LT) antagonist. | Nakagawa, N., et al. 1992. Jpn J Pharmacol. 60: 217-25. PMID: 1337128
- A novel leukotriene antagonist, ONO-1078, inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. | Yamaguchi, T., et al. 1992. Am Rev Respir Dis. 146: 923-9. PMID: 1416420
- Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats. | Zhang, LH. and Wei, EQ. 2003. Acta Pharmacol Sin. 24: 1241-7. PMID: 14653951
- In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. | Obata, T., et al. 1992. Jpn J Pharmacol. 60: 227-37. PMID: 1491512
- ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats. | Zhang, LH. and Wei, EQ. 2005. Acta Pharmacol Sin. 26: 435-40. PMID: 15780192
- Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors. | Yagami, T., et al. 2013. Neurochem Int. 63: 163-71. PMID: 23792223
- ONO-1078: an antagonist of leukotrienes. | Obata, T., et al. 1987. Adv Prostaglandin Thromboxane Leukot Res. 17A: 540-3. PMID: 2959110
- Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury. | Ishizaka, A., et al. 1994. Am J Respir Crit Care Med. 150: 1325-31. PMID: 7952560
- Effects of ONO-1078, a leukotriene antagonist, on cardiovascular responses induced by vagal stimulation, capsaicin, and substance P in guinea pigs. | Wei, EQ., et al. 1995. Zhongguo Yao Li Xue Bao. 16: 485-8. PMID: 8732038
- ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | Tominaga, M., et al. 1996. J Pharmacol Exp Ther. 278: 1058-63. PMID: 8819486
- Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. | Nagayama, S., et al. 1998. Cancer Lett. 130: 175-82. PMID: 9751271
Inhibitor of:
5-LO, CCL (C-C motif chemokine ligand), CysLT1 Receptor, eotaxin, GPR-44, LF, LTB4DH, MCP-4, REEP5, and Selenoprotein O.Activator of:
CysLT2 Receptor, FLAP, and GPR17.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ONO 1078, 50 mg | sc-204148 | 50 mg | $65.00 |