Molecular structure of BX 471, CAS Number: 217645-70-0
BX 471 (CAS 217645-70-0)
Alternate Names:
N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea
CAS Number:
217645-70-0
Molecular Weight:
434.9
Molecular Formula:
C21H24ClFN4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BX 471 (CAS 217645-70-0) References
- DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis. | Liao, WC., et al. 2019. Am J Cancer Res. 9: 347-362. PMID: 30906633
- SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7. | Chen, J., et al. 2020. Oncogene. 39: 5536-5552. PMID: 32616889
- Therapeutic Effect of C-C Chemokine Receptor Type 1 (CCR1) Antagonist BX471 on Allergic Rhinitis. | Feng, S., et al. 2020. J Inflamm Res. 13: 343-356. PMID: 32801828
- Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation. | Du, X., et al. 2021. Signal Transduct Target Ther. 6: 91. PMID: 33640900
- Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice. | Weber, SN., et al. 2021. Biochem Biophys Rep. 27: 101077. PMID: 34337167
- Blockade of CCR1 induces a phenotypic shift in macrophages and triggers a favorable antilymphoma activity. | Le, K., et al. 2023. Blood Adv. 7: 3952-3967. PMID: 36630565
- Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis. | Li, H., et al. 2024. Metabolism. 151: 155758. PMID: 38070823
- The interplay of Cxcl10+/Mmp14+ monocytes and Ccl3+ neutrophils proactively mediates silica-induced pulmonary fibrosis. | Cheng, D., et al. 2024. J Hazard Mater. 467: 133713. PMID: 38335607
- Palmatine Attenuated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting M1 Phenotype Macrophage Polarization via NAMPT/TLR2/CCR1 Signaling. | Wang, L., et al. 2024. J Agric Food Chem.. PMID: 38619332
- Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ. | Xu, H., et al. 2024. Mol Med. 30: 74. PMID: 38831316
Inhibitor of:
CCL (C-C motif chemokine ligand), Ccr1l1, CKR-1, CKR-4, CXCL13, I-309, IL-8RB, MIP-1γ, and OTTMUSG00000006698.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BX 471, 5 mg | sc-507448 | 5 mg | $240.00 |