The Coiled-Coil Domain Containing 8 (CCDC8) protein is an integral part of human cellular machinery, encoded by the CCDC8 gene. This protein has been implicated in crucial cellular processes, most notably in the context of genomic stability and cell proliferation. Research into CCDC8 has revealed its involvement in the maintenance of the structural integrity of chromosomes during cell division. As a result, CCDC8 is considered a significant player in the normal growth and development of skeletal structures. Its precise function, however, extends beyond skeletal development, hinting at a broader role in cellular homeostasis. The regulation of CCDC8 expression is a sophisticated affair, influenced by intricate cellular signaling pathways and transcriptional networks. Understanding the elements that can induce CCDC8 expression is of considerable interest in the field of molecular biology, as it provides insights into the gene's regulation and its overarching role in cellular physiology.
On the molecular level, various chemical compounds have been identified that can potentially serve as activators of CCDC8 expression. These compounds, which range from naturally occurring polyphenols to synthetic molecules, may influence the expression of CCDC8 through diverse mechanisms. For instance, molecules like Resveratrol and Curcumin, both known for their roles in modulating cellular signaling cascades, could potentially stimulate the expression of CCDC8 by interacting with specific transcription factors or by initiating a series of intracellular events leading to gene activation. Other compounds such as Retinoic Acid and Vitamin D3 may also serve as potential activators by binding to their respective receptors, thereby promoting gene expression. Additionally, compounds like Sulforaphane and Quercetin are recognized for their ability to induce antioxidant responses, which could, in turn, lead to the upregulation of genes, including CCDC8. Moreover, dietary elements such as Zinc, when presented in the form of Zinc Sulphate, could enhance CCDC8 expression by serving as essential cofactors for the proper function of DNA-binding proteins involved in gene transcription. These activators represent a comprehensive array of molecules that, through their interaction with cellular processes, could potentially increase the expression of the CCDC8 protein. It is through the meticulous study of these compounds that researchers can further elucidate the regulation and function of CCDC8 within the cell.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may upregulate CCDC8 by activating sirtuin pathways, which are implicated in cellular stress responses and longevity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could potentially stimulate CCDC8 expression through its interaction with various signaling molecules such as NF-κB, which plays a role in cellular response to stimuli. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid may induce the expression of CCDC8 by binding to retinoic acid receptors, which act as transcription factors for gene expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol can upregulate CCDC8 by engaging with the vitamin D receptor, leading to the transcriptional activation of target genes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could stimulate the expression of CCDC8 by inducing antioxidant response elements and modifying histone acetylation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to upregulate various genes through its antioxidant properties and may similarly increase CCDC8 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein may induce CCDC8 expression due to its function as a phytoestrogen, potentially interacting with estrogen receptors that can upregulate gene expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could induce the expression of CCDC8 by acting as a synthetic glucocorticoid and binding to glucocorticoid receptors, which may stimulate the transcription of target genes. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin may upregulate CCDC8 through the activation of the AMPK pathway, leading to a cascade of events that culminates in enhanced gene transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can stimulate the increase of CCDC8 by elevating cAMP levels, which in turn activates protein kinase A (PKA) and leads to the activation of transcription factors. |