Date published: 2025-9-12

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CCDC8 Activators

The Coiled-Coil Domain Containing 8 (CCDC8) protein is an integral part of human cellular machinery, encoded by the CCDC8 gene. This protein has been implicated in crucial cellular processes, most notably in the context of genomic stability and cell proliferation. Research into CCDC8 has revealed its involvement in the maintenance of the structural integrity of chromosomes during cell division. As a result, CCDC8 is considered a significant player in the normal growth and development of skeletal structures. Its precise function, however, extends beyond skeletal development, hinting at a broader role in cellular homeostasis. The regulation of CCDC8 expression is a sophisticated affair, influenced by intricate cellular signaling pathways and transcriptional networks. Understanding the elements that can induce CCDC8 expression is of considerable interest in the field of molecular biology, as it provides insights into the gene's regulation and its overarching role in cellular physiology.

On the molecular level, various chemical compounds have been identified that can potentially serve as activators of CCDC8 expression. These compounds, which range from naturally occurring polyphenols to synthetic molecules, may influence the expression of CCDC8 through diverse mechanisms. For instance, molecules like Resveratrol and Curcumin, both known for their roles in modulating cellular signaling cascades, could potentially stimulate the expression of CCDC8 by interacting with specific transcription factors or by initiating a series of intracellular events leading to gene activation. Other compounds such as Retinoic Acid and Vitamin D3 may also serve as potential activators by binding to their respective receptors, thereby promoting gene expression. Additionally, compounds like Sulforaphane and Quercetin are recognized for their ability to induce antioxidant responses, which could, in turn, lead to the upregulation of genes, including CCDC8. Moreover, dietary elements such as Zinc, when presented in the form of Zinc Sulphate, could enhance CCDC8 expression by serving as essential cofactors for the proper function of DNA-binding proteins involved in gene transcription. These activators represent a comprehensive array of molecules that, through their interaction with cellular processes, could potentially increase the expression of the CCDC8 protein. It is through the meticulous study of these compounds that researchers can further elucidate the regulation and function of CCDC8 within the cell.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol may upregulate CCDC8 by activating sirtuin pathways, which are implicated in cellular stress responses and longevity.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin could potentially stimulate CCDC8 expression through its interaction with various signaling molecules such as NF-κB, which plays a role in cellular response to stimuli.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic Acid may induce the expression of CCDC8 by binding to retinoic acid receptors, which act as transcription factors for gene expression.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

Cholecalciferol can upregulate CCDC8 by engaging with the vitamin D receptor, leading to the transcriptional activation of target genes.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

DL-Sulforaphane could stimulate the expression of CCDC8 by inducing antioxidant response elements and modifying histone acetylation.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin is known to upregulate various genes through its antioxidant properties and may similarly increase CCDC8 expression.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein may induce CCDC8 expression due to its function as a phytoestrogen, potentially interacting with estrogen receptors that can upregulate gene expression.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone could induce the expression of CCDC8 by acting as a synthetic glucocorticoid and binding to glucocorticoid receptors, which may stimulate the transcription of target genes.

Metformin-d6, Hydrochloride

1185166-01-1sc-218701
sc-218701A
sc-218701B
1 mg
5 mg
10 mg
$286.00
$806.00
$1510.00
1
(1)

Metformin may upregulate CCDC8 through the activation of the AMPK pathway, leading to a cascade of events that culminates in enhanced gene transcription.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin can stimulate the increase of CCDC8 by elevating cAMP levels, which in turn activates protein kinase A (PKA) and leads to the activation of transcription factors.