CCDC6 Inhibitors
CCDC6 inhibitors refer to a class of chemical compounds designed to interact with the coiled-coil domain containing 6 (CCDC6) protein. The CCDC6 protein is a cellular protein that plays a pivotal role in various cellular processes, including the maintenance of genomic stability, cell cycle control, and the regulation of transcription and apoptosis. Inhibitors targeting CCDC6 are typically small molecules that can bind to the protein, potentially affecting its normal function. The interaction between these inhibitors and CCDC6 can lead to a modulation of the protein's activity, which is of interest in the study of molecular biology and cellular biochemistry. These inhibitors are often the product of targeted medicinal chemistry efforts aiming to achieve high specificity and potency while minimizing off-target effects.
The development of CCDC6 inhibitors is based on a deep understanding of the protein's structure and the pathways in which it is involved. CCDC6 has a characteristic coiled-coil domain, which is a structural motif that facilitates protein-protein interactions. The domain is characterized by a series of alpha-helices that twist around each other to form a stable, rod-like structure. Inhibitors are designed to specifically bind to this domain or to other critical regions of the protein, which can result in an alteration of its conformation and, consequently, its function. Research on CCDC6 inhibitors focuses on the synthesis and characterization of these compounds, including the determination of their binding affinities, specificity, and the exact nature of their interaction with the CCDC6 protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that prevents Akt phosphorylation. Since CCDC6 is involved in DNA repair processes mediated by the PI3K/Akt pathway, its activity can be modulated by LY294002. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor targeting the ERK pathway. CCDC6, if associated with ERK signaling, can have its function influenced by PD98059. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor. Given the role of CCDC6 in the DNA damage response, inhibiting PARP, which is involved in DNA repair, can potentially affect the functional dynamics of CCDC6 in the cell. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR inhibitor. CCDC6, being involved in DNA damage response, can have its functions modulated when ATR, another kinase involved in DNA repair, is inhibited by VE-821. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2-p53 interaction inhibitor. By stabilizing p53 and promoting its activation, Nutlin-3 can modulate pathways in which CCDC6 operates, especially if CCDC6 and p53 pathways intersect. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor. By affecting transcriptional elongation and modulating chromatin states, JQ1 can indirectly affect the genomic regions where CCDC6 operates or is transcribed from. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
NEDD8-activating enzyme inhibitor. Given the potential ubiquitination and proteasomal degradation events that proteins like CCDC6 might undergo, MLN4924 can play a role in modulating its stability. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB pathway inhibitor. Since NF-κB signaling can influence many cellular processes, including DNA repair, it's possible that CCDC6 function could be influenced by BAY 11-7082. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
DNA-PK inhibitor. As CCDC6 is involved in DNA repair, inhibiting DNA-PK, another enzyme in DNA repair pathways, with NU7441 can modulate the role of CCDC6 in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, which can influence any downstream effects or modulation of CCDC6 potentially linked to JNK signaling. | ||||||