CCDC6 Activators
CCDC6 activators refer to a class of chemical compounds designed to modulate the activity of the coiled-coil domain containing 6 (CCDC6) protein. The CCDC6 gene, initially identified as part of a fusion with RET proto-oncogene in thyroid carcinomas, encodes a protein that plays a crucial role in various cellular processes, including the maintenance of genomic stability and the regulation of cell division. The importance of CCDC6 lies in its involvement in the cellular response to DNA damage and its interaction with other proteins that are essential for the repair of double-strand breaks in DNA. By influencing the activity of CCDC6, activators can affect the protein's ability to fulfill its roles within the cell. Given the significance of DNA repair mechanisms in maintaining cellular integrity, the regulation of CCDC6 activity can have a substantial impact on genomic stability.
The mechanism of action for CCDC6 activators typically involves the binding of these molecules to the CCDC6 protein, resulting in an alteration of its conformation, stability, or interaction with other proteins. This binding can either enhance or restore the protein's function, depending upon the nature of the interaction and the specific compound involved. CCDC6 activators may target the protein directly or indirectly influence the pathways or molecular complexes that CCDC6 is a part of. While the biochemical pathways and interactions of CCDC6 are complex and multifaceted, the precise modulation of its activity through activators can shed light on the protein's role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea induces DNA damage and replication stress, potentially increasing the need for CCDC6 in DNA damage response pathways. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA cross-links, which may enhance the DNA damage response and hence possibly increase CCDC6 activation. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
MMS induces DNA alkylation damage. CCDC6, being involved in DNA repair, might be activated as a compensatory response. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytosine analog that causes DNA demethylation, potentially influencing the expression and activation of CCDC6. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide induces DNA double-strand breaks. This severe DNA damage can enhance the role and activation of CCDC6. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits topoisomerase I, leading to DNA damage which may escalate the need for CCDC6 in repair pathways. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, affecting cell cycle dynamics, which could indirectly involve and activate CCDC6. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $206.00 $612.00 $1020.00 $2856.00 | 38 | |
Bleomycin induces DNA breaks. The resulting DNA damage might necessitate a heightened activation or role for CCDC6. | ||||||