CCDC24 Inhibitors
CCDC24 inhibitors encompass a diverse array of chemical compounds that intricately diminish the protein's functional activity through various intracellular signaling pathways. Staurosporine, Wortmannin, LY 294002, Chelerythrine, Gö 6983, and GF109203X converge on the common mechanism of inhibiting kinase activity; these inhibitors collectively reduce the phosphorylation potential within cells, a critical modification that could be essential for CCDC24's activity. By impeding kinases such as PI3K, PKC, and other nonspecific kinases, these compounds may prevent phosphorylation-dependent localization or activation of CCDC24, thereby indirectly inhibiting its function. Moreover, compounds like Wortmannin and LY 294002 specifically target the PI3K pathway, which, by curtailing PIP3 formation, could restrict CCDC24's recruitment to the membrane if it is associated with PIP3-dependent signaling complexes.
Additionally, Rapamycin, Cyclosporin A, SB 203580, PD 98059, 2-APB,and BAPTA/AM contribute to the functional inhibition of CCDC24 by modulating distinct cellular processes and pathways. Rapamycin, by inhibiting mTOR, could lead to a broad decrease in protein synthesis, including CCDC24, if its expression is under mTOR control. Cyclosporin A, through its inhibition of calcineurin, may diminish CCDC24 activity if it is regulated by dephosphorylation events in calcium-dependent pathways. Inhibitors such as SB 203580 and PD 98059 target the MAPK signaling axis, with potential repercussions on CCDC24 activity if it is intertwined with this pathway. The calcium dynamics within the cell are crucial for numerous signaling cascades, and the interference by 2-APB, an IP3 receptor antagonist, and BAPTA/AM, a calcium chelator, suggests a decrease in CCDC24 activity if it is calcium-sensitive. These inhibitors collectively elucidate the multifaceted approaches to diminishing CCDC24's functional presence within cellular signaling, showcasing the complexity and interconnectivity of intracellular inhibition mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A non-selective kinase inhibitor, Staurosporine can inhibit a wide range of kinases that phosphorylate CCDC24, thus diminishing its phosphorylation state and potentially dampening its activity if phosphorylation is required for its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, Wortmannin reduces the production of PIP3, a lipid molecule that recruits and activates proteins involved in survival and growth pathways. A decrease in PIP3 could lead to reduced activity of downstream effectors that may include CCDC24 if it is involved in these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, Rapamycin blocks the mammalian target of rapamycin pathway, which could lead to decreased protein synthesis and indirectly inhibit proteins downstream or associated with this pathway, including CCDC24 if it is implicated. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that inhibits calcineurin, Cyclosporin A could prevent the dephosphorylation of proteins regulated by calcium-dependent pathways. If CCDC24 activity is modulated by such pathways, its functional activity could be diminished. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor, LY 294002 prevents the formation of PIP3, similar to Wortmannin, potentially reducing the recruitment of proteins like CCDC24 to the membrane and diminishing its cellular activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
A PKC inhibitor, Chelerythrine blocks protein kinase C activity, which could lead to a decrease in phosphorylation events that might be necessary for CCDC24's function if it is regulated by PKC-mediated signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor, SB 203580 can suppress the p38 MAPK pathway, which may decrease the activity of proteins that are regulated by this pathway. If CCDC24 is one such protein, its activity would be diminished. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor, PD 98059 interferes with the MAPK/ERK pathway, potentially reducing the activation of proteins that operate downstream or in parallel. If CCDC24 is functionally linked to this pathway, its activity could be indirectly inhibited. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A broad PKC inhibitor, Gö 6983 could reduce the phosphorylation of CCDC24 if it is a substrate of PKC, leading to decreased activity of CCDC24. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
An IP3 receptor antagonist, 2-APB inhibits the release of calcium from the endoplasmic reticulum. If CCDC24 is regulated by calcium signaling, this compound could lead to its functional inhibition. | ||||||