CCDC148 Activators
CCDC148 Activators encompass a diverse array of chemical compounds that influence various biochemical pathways, ultimately leading to the enhanced activity of CCDC148. Forskolin and IBMX both elevate intracellular cAMP levels, which can activate protein kinase A (PKA). PKA, in turn, has the potential to phosphorylate CCDC148, augmenting its activity assuming that CCDC148 is a substrate for PKA. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may phosphorylate CCDC148 directly or modulate its activity indirectly through downstream signaling elements. Ionomycin and A23187, as calcium ionophores, boost intracellular calcium and may trigger calcium-dependent kinases that activate CCDC148. Sodium orthovanadate inhibits tyrosine phosphatases, potentially increasing phosphorylation and activation of CCDC148 if it is regulatedby tyrosine phosphorylation. Epigallocatechin gallate (EGCG) functions as a kinase inhibitor and could reduce negative regulation on CCDC148, leading to its activation.
In addition, LY294002, as a PI3K/Akt pathway inhibitor, may instigate the activation of alternative signaling routes that could include CCDC148, enhancing its activity. Sphingosine-1-phosphate and its receptor interactions might initiate signaling cascades involving CCDC148 activation. The application of a nitric oxide donor like SNAP can lead to an increase in cyclic GMP, which may activate kinases that phosphorylate and thus activate CCDC148. Anisomycin activates stress-activated protein kinases (SAPKs) which could include CCDC148 in their phosphorylation targets. Finally, U0126, by inhibiting MEK, may redirect cellular signaling in a way that upregulates CCDC148 activity, providing that it is not normally activated by the MAPK pathway. Each of these compounds, through their specific actions on cellular signaling pathways, serves to enhance the functional activity of CCDC148 without increasing its expression or directly stimulating its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing levels of cAMP. Elevated cAMP enhances the activity of protein kinase A (PKA), which can then phosphorylate CCDC148, potentially increasing its activity if CCDC148 is a PKA substrate. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX can indirectly lead to the activation of PKA and subsequent phosphorylation of CCDC148. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which may phosphorylate CCDC148 or regulate its activity through phosphorylation of associated proteins or signaling pathways that include CCDC148. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent kinases such as calmodulin-dependent kinase, which could then activate CCDC148 if it is regulated by calcium signaling. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a general inhibitor of tyrosine phosphatases. Inhibition of these phosphatases can result in increased phosphorylation levels of proteins, including CCDC148, if it is regulated by tyrosine phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that may impact specific kinases within the cell. If CCDC148 activity is regulated by a kinase that EGCG inhibits, this could result in an increased activity of CCDC148 due to reduced negative regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway. By inhibiting this pathway, LY294002 could lead to the compensatory activation of alternative pathways that may include activation of CCDC148. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that can activate sphingosine-1-phosphate receptors, potentially leading to signaling cascades that involve the activation of CCDC148 if it is part of such pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, similar to ionomycin, and could activate CCDC148 through calcium-dependent signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs) indirectly. This activation may lead to the phosphorylation and activation of CCDC148, assuming it is a SAPK substrate. | ||||||