casein kinase Iα Activators
Casein kinase Iα (CKIα) activators are a class of chemical compounds that play a crucial role in regulating various cellular processes through the modulation of the activity of the protein kinase CKIα. CKIα is a serine/threonine protein kinase that is part of a family of kinases involved in the phosphorylation of numerous substrates within the cell. These substrates are implicated in a wide range of cellular functions, including the regulation of circadian rhythms, cell cycle progression, apoptosis, and the modulation of various signaling pathways. CKIα, in particular, has been extensively studied due to its pivotal role in circadian rhythm regulation, where it phosphorylates key clock proteins, influencing their stability and function.
CKIα activators are designed to enhance the kinase activity of CKIα, ultimately leading to increased phosphorylation of its downstream targets. These compounds typically work by binding to CKIα and promoting its active conformation, thereby augmenting its catalytic activity. By doing so, they can impact various cellular processes that are influenced by CKIα-mediated phosphorylation events. Understanding the mechanisms and effects of CKIα activators is of great interest in both basic research and potential applications in various fields, as they offer a means to manipulate and study the intricate cellular processes controlled by CKIα.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a crucial role in cell growth and differentiation, potentially affecting the expression of CKIα. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is known to activate adenylate cyclase, leading to an increase in cAMP levels, which may influence the expression of various proteins, including CKIα. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is known to activate protein kinase C, potentially influencing signaling pathways and the expression of proteins like CKIα. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to inhibit glycogen synthase kinase-3 (GSK-3), potentially leading to changes in the Wnt signaling pathway and affecting CKIα expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that has been shown to influence gene expression and potentially increase the expression of proteins such as CKIα. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog, which incorporates into DNA and RNA, potentially leading to demethylation of DNA and affecting gene expression, including that of CKIα. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can influence gene expression and cellular signaling pathways, potentially affecting the expression of CKIα. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can influence chromatin structure and gene expression, potentially leading to increased expression of proteins such as CKIα. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol found in grapes and red wine, known for its antioxidant properties. It may also affect signaling pathways and gene expression, potentially influencing CKIα expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the active component of turmeric, has anti-inflammatory and antioxidant properties. It may also influence various signaling pathways, potentially leading to changes in CKIα expression. | ||||||