Cas-L Activators
The chemical class of Cas-L Activators includes compounds that can indirectly influence the activity of Cas-L through modulation of various cellular pathways, particularly those related to integrin signaling. Cas-L is a scaffold protein that plays a pivotal role in integrin-dependent signaling, which is essential for cell adhesion, migration, and metastasis in cancer. The indirect modulation of Cas-L activity by these chemicals underscores the complexity of cellular signaling networks and the integrative nature of scaffold proteins in coordinating these responses.
The compounds in this class, such as growth factors, extracellular matrix components, kinase inhibitors, and integrin modulators, act through distinct but interconnected pathways. Growth factors like EGF and components of the extracellular matrix, such as fibronectin and collagen, initiate signaling cascades that intersect with integrin pathways, impacting the function of Cas-L. Kinase inhibitors, including those targeting FAK and Src, and PI3K inhibitors like LY294002, modulate critical signaling nodes that influence integrin signaling and, consequently, Cas-L activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA acts through its G protein-coupled receptors to activate downstream signaling cascades that intersect with integrin signaling pathways, potentially influencing Cas-L activity. | ||||||
Fibronectin | sc-29011 sc-29011A | 1 mg 5 mg | $140.00 $494.00 | 94 | ||
An extracellular matrix component, fibronectin interacts with integrins, activating signaling pathways that can indirectly modulate Cas-L activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitors like Y-27632 modulate the Rho signaling pathway, which is involved in cytoskeletal dynamics and interacts with integrin signaling, potentially affecting Cas-L. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Src kinase is involved in integrin signaling pathways. Inhibiting Src kinase with compounds like Dasatinib can modulate these pathways, indirectly affecting Cas-L activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitors can modulate the PI3K/Akt pathway, which interacts with integrin signaling, potentially influencing Cas-L activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophores increase intracellular calcium levels, affecting various signaling pathways, including those involving integrins and potentially Cas-L. | ||||||
Collagen IV | sc-29010 | 1 mg | $220.00 | 11 | ||
Collagen, a major component of the extracellular matrix, can activate integrin signaling pathways, indirectly influencing Cas-L activity. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Inhibitors of PDGF receptors can modulate signaling pathways involving integrins, potentially affecting Cas-L activity. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
Matrix metalloproteinases interact with the extracellular matrix and integrins. Inhibiting these enzymes with Marimastat can modulate integrin signaling, indirectly affecting Cas-L activity. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Integrin antagonists like Cilengitide modulate integrin-mediated signaling, potentially influencing Cas-L activity. | ||||||