Collagen IV: sc-29010

Collagen IV is a crucial component of the extracellular matrix (ECM) that forms a specialized structure known as the basement membrane, which is essential for various physiological processes. It is a network-forming collagen, distinct in its ability to assemble into a sheet-like mesh, making it fundamental to the structural integrity and filtration properties of the basement membranes found in endothelial and epithelial tissues. Scientifically, Collagen IV has been extensively studied for its role in cellular behavior, tissue development, and morphogenesis. Its unique triple-helical structure, composed of three alpha chains (α1 through α6), enables the formation of a scaffold that supports cell adhesion, migration, and differentiation. Research on Collagen IV has revealed its significant function in regulating the basement membrane′s mechanical properties, influencing both its rigidity and porosity, which are critical for cellular organization and function. Collagen IV is often utilized to create biomimetic environments for in vitro studies tissue engineering, and organotypic culture models. The ability of Collagen IV to interact with other ECM proteins and cellular receptors such as integrins has been a focal point in studies examining cell-ECM interactions, angiogenesis, and barrier function in both normal and pathological states.