CARD14 Activators
CARD14 Activators are a collection of chemical compounds that facilitate the enhancement of CARD14 activity through specific cellular signaling pathways. The activators work by engaging with pathways that CARD14 is known to participate in or influence, particularly those involved in NF-kB signaling, which is a key pathway in inflammatory and immune responses. CARD14 Activators consist of a diverse range of chemical compounds that indirectly augment the functional activity of CARD14 through distinct signaling pathways and cellular processes. Phorbol 12-myristate 13-acetate (PMA) enhances CARD14 function by activating protein kinase C (PKC), which in turn can trigger NF-kB signaling, a pathway where CARD14 plays a pivotal role. Ionomycin raises intracellular calcium levels, thus potentially facilitating CARD14's involvement in calcium-dependent NF-kB activation. Resveratrol and curcumin, through their effects on sirtuin 1 (SIRT1) and inhibition of IKKβ respectively, contribute to the regulation of NF-kB activity, thereby indirectly promoting CARD14's role in inflammatory signaling.
Continuing, Bisindolylmaleimide I, by selectively inhibiting certain PKC isoforms, may shift the balance of signaling towards PKC-theta, enhancing CARD14-mediated activation of NF-kB. Anisomycin, as a JNK pathway activator, and prostratin, through PKC activation, both indirectly support CARD14's function in immune response signaling. Roscovitine's inhibition of cyclin-dependent kinases may alter cell cycle-related pathways, thus influencing CARD14 activity, while oligomycin A's impact on ATP synthesis could trigger stress-responsive pathways that enhance CARD14's role. Furthermore, manumycin A, by inhibiting Ras farnesyltransferase and the IkB kinase complex, can also modulate NF-kB signaling, providing additional support for CARD14 activation. Collectively, these CARD14 Activators, by targeting specific molecules and pathways, facilitate the enhancement of CARD14's involvement in crucial signaling processes without directly upregulating its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in various signaling pathways. CARD14, a member of the CARD protein family, is known to interact with PKC-theta, a PKC isoform. Activation of PKC-theta by PMA can lead to the activation of NF-kB signaling, enhancing the functional activity of CARD14 in immune responses. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. CARD14 is part of pathways that can be modulated by calcium signaling. The elevation of intracellular calcium by Ionomycin may facilitate CARD14's role in activating NF-kB and other calcium-dependent signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol known to activate sirtuin 1 (SIRT1), which deacetylates proteins and plays a role in cellular stress responses. CARD14 can be impacted by SIRT1 activation, as SIRT1 may influence NF-kB activity, thus indirectly enhancing CARD14's role in inflammatory signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, can inhibit the activity of IKKβ, leading to the enhancement of NF-kB activity. Given CARD14's involvement in NF-kB signaling, curcumin indirectly promotes the functional activity of CARD14 in immune and inflammatory processes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors (S1PRs), leading to downstream effects on cellular processes including NF-kB activation. CARD14 activity is associated with NF-kB signaling, and S1P can facilitate this by acting through S1PRs. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-kB activation by blocking the phosphorylation of IκBα. CARD14, which is involved in NF-kB signaling, can be indirectly activated when alternative NF-kB activation pathways are enhanced due to IκBα stabilization. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific PKC inhibitor that can modulate signaling pathways by affecting PKC activity. CARD14 interacts with PKC-theta; thus, selective inhibition of other PKC isoforms may shift signaling dynamics to augment CARD14-mediated NF-kB activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator which can stimulate the JNK pathway, leading to transcriptional activation events. CARD14 is known to be involved in pathways that can be influenced by JNK signaling, and the activation of JNK by anisomycin could indirectly enhance CARD14's functional activity. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin is a non-tumor-promoting phorbol ester that activates PKC isoforms. Through PKC activation, prostratin can initiate signaling cascades that lead to NF-kB activation, thus indirectly enhancing the functional activity of CARD14 in immune signaling. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase (CDK) inhibitor that may influence various cell cycle-related pathways. Since CARD14 is involved in NF-kB signaling, roscovitine's effects on cell cycle regulation can indirectly result in alteration of CARD14's activity in immune response pathways. | ||||||